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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Preventive effects of cyclohexenonic long-chain fatty alcohol on diabetic cystopathy in the rat.
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Preventive effects of cyclohexenonic long-chain fatty alcohol on diabetic cystopathy in the rat.

机译：己烯酮长链脂肪醇对大鼠糖尿病性膀胱病变的预防作用。

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In this study, we investigated the preventive effect of n-hexacosanol on diabetes-induced bladder dysfunction in the rat. Diabetes was induced in 8-week-old male Sprague-Dawley rats by administering an injection of streptozotocin (50 mg/kg, i.p.). The rats were randomly divided into 4 groups (age-matched control rats, diabetic rats without treatment with n-hexacosanol, and diabetic rats treated with n-hexacosanol (2 and 8 mg/kg, i.p. every day)) and maintained for 4 weeks. The serum glucose and serum insulin levels were determined, and the functions of bladder were estimated by voiding behavior, cystometric, and functional studies to carbachol and KCl. Furthermore, we examined possible diabetic induced histological changes in these rats. Treatment with n-hexacosanol did not alter diabetic status including body mass, bladder mass, and serum glucose and serum insulin levels, but significantly improved the maximum contraction pressure of the detrusor and residual urine volume in cystometric studies and Emax values to carbachol in functional studies in a dose-dependent manner. Diabetes induced bladder smooth muscle hypertrophy, which tended to be ameliorated by treatment with n-hexacosanol in a dose-dependent manner. Treatment with n-hexacosanol did not alter the diabetic status, but significantly improved diabetic cystopathy in a dose-dependent manner.
机译：在这项研究中，我们调查了正己醇对大鼠糖尿病引起的膀胱功能障碍的预防作用。通过注射链脲佐菌素（50 mg / kg，腹腔注射）在8周大的Sprague-Dawley雄性大鼠中诱发糖尿病。将大鼠随机分为4组（年龄匹配的对照组大鼠，未用正己醇治疗的糖尿病大鼠和用正己醇（2和8 mg / kg，每天腹腔注射）治疗的糖尿病大鼠）并维持4周。测定血清葡萄糖和血清胰岛素水平，并通过排尿行为，膀胱测压和对卡巴胆碱和氯化钾的功能研究来评估膀胱的功能。此外，我们检查了这些大鼠中糖尿病诱发的组织学变化。用正己醇治疗不会改变糖尿病状态，包括体重，膀胱质量，血清葡萄糖和血清胰岛素水平，但在膀胱测量法中功能显着改善了逼尿肌的最大收缩压力和残余尿量，在功能研究中改善了卡巴胆碱的Emax值以剂量依赖的方式。糖尿病引起的膀胱平滑肌肥大，通过用正己醇进行剂量依赖性的治疗，往往会改善。用正己醇治疗并没有改变糖尿病状态，但是以剂量依赖的方式显着改善了糖尿病性膀胱病变。

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