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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of Rhus tripartitum fruit extract on CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats
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Effects of Rhus tripartitum fruit extract on CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats

机译：三方大黄果实提取物对大鼠四氯化碳肝毒性和顺铂肾毒性的影响

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摘要

Rhus tripartitum D.C., Anacardiaceae, has traditionally been used in Tunisia against many illnesses. The present study investigates, for the first time, the protective effects of the methanol extract of Rhus tripartitum fruit (MERT) against CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicty in Wistar rats. ALT, AST, LDH, GGT, creatinin, urea, and uric acid levels were studied. The changes in antioxidant parameters such as malondialdehyde (MDA) and protein carbonyl contents were also determined. The increased levels of MDA (30.97 and 11.50 nmol MDA/mg protein in liver and kidney, respectively) and protein carbonyls (13.4 and 17.95 nmol/mg protein in liver and kidney, respectively) were attenuated by MERT pretreatment (19.35 and 6.1 nmol MDA/mg protein and 9.15 and 12 nmol/mg protein in liver and kidney, respectively). The MERT pretreatment significantly reduced the increased biochemical parameters of liver and kidney caused by CCl4 and cisplatin treatment. The histopathologic observation showed that MERT pretreatment restores the altered tissues. The observed results could be due to the high phenolic content and to MERT's important antioxidant potential. This study supports the hepatoprotective and nephroprotective effects of R. tripartitum.
机译：传统上，Anacardiaceae的Rhus tripartitum D.C.在突尼斯已被用来抵抗多种疾病。本研究首次研究了三方大黄果实的甲醇提取物（MERT）对Wistar大鼠CCl4诱导的肝毒性和顺铂诱导的肾毒性的保护作用。研究了ALT，AST，LDH，GGT，肌酐，尿素和尿酸水平。还确定了抗氧化参数的变化，例如丙二醛（MDA）和蛋白质羰基含量。 MERT预处理（19.35和6.1 nmol MDA）减弱了MDA（分别在肝脏和肾脏中分别为30.97和11.50 nmol MDA / mg蛋白）和羰基蛋白（分别在肝脏和肾脏中分别为13.4和17.95 nmol / mg蛋白）的水平。 / mg蛋白以及肝脏和肾脏中的9.15和12 nmol / mg蛋白）。 MERT预处理显着降低了CCl4和顺铂治疗引起的肝脏和肾脏生化指标的提高。组织病理学观察表明，MERT预处理可恢复改变的组织。观察到的结果可能归因于高酚含量和MERT重要的抗氧化剂潜力。这项研究支持三方丁香的肝保护和肾保护作用。

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