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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >In vitro evaluation of percutaneous diffusion of uranyl nitrate through intact or excoriated skin of rat and pig.
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In vitro evaluation of percutaneous diffusion of uranyl nitrate through intact or excoriated skin of rat and pig.

机译：体外评估大鼠和猪皮肤中未受硝酸盐或硝酸铀酰经皮扩散的体外评估。

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摘要

At the present time, the International Commission on Radiological Protection (ICRP) has not published any model concerning internal radioactive contamination by uptake from wounds. The aims of our work were to determine the time available to treat contamination of intact or wounded skin before a significant uptake of uranium occurred and to evaluate the consequences of incomplete decontamination on uranium uptake. The kinetics of percutaneous diffusion of uranium through intact or excoriated skin and its distribution in skin layers were evaluated using an in vitro technique. Our data demonstrated a dramatic increase of uranium percutaneous diffusion through excoriated skin compared with intact skin. Significant uptake of uranium through excoriated skin occurred in only 30 min, indicating that there is only a short interval available to treat a contaminated wound effectively. Moreover, in the case of an incompletely decontaminated superficial wound, viable epidermis behaved as a reservoir for uranium that remained bioavailable. At the present time, potential uptake of uranium and perhaps other radionuclides through intact or wounded skin is not adequately taken into account by radiological protection agencies. Our results emphasize the need for further study and modeling of uptake of radionuclides through intact or wounded skin.
机译：目前，国际放射防护委员会（ICRP）尚未发布任何有关伤口吸收内部放射性污染的模型。我们工作的目的是确定可利用的时间来处理完整的或受伤的皮肤污染，然后再大量吸收铀，并评估不完全净化对铀吸收的影响。使用体外技术评估了铀通过完整或游离皮肤经皮扩散的动力学及其在皮肤层中的分布。我们的数据表明，与完整的皮肤相比，铀通过经皮毛发皮肤的扩散显着增加。仅在30分钟内，游离皮肤就吸收了大量铀，这表明有效治疗受污染伤口的时间间隔很短。此外，在未完全净化的浅表伤口的情况下，可行的表皮表现为仍可生物利用的铀储库。目前，放射防护机构尚未充分考虑到通过完整或受伤的皮肤可能吸收的铀以及可能的其他放射性核素。我们的结果强调需要对完整或受伤皮肤吸收放射性核素进行进一步研究和建模。

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