...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats.
【24h】

Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats.

机译：肝内腺苷介导的肝肾反射激活是通过大鼠的A1受体进行的。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous studies have shown that intrahepatic adenosine is involved in activation of the hepatorenal reflex that regulates renal sodium and water excretion. The present study aims to determine which subtype of adenosine receptors is implicated in the process. Mean arterial pressure, portal venous pressure and flow, and renal arterial flow were monitored in pentobarbital anesthetized rats. Urine was collected from the bladder. Intraportal administration of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist, increased urine flow by 24%, 89%, and 143% at the dose of 0.01, 0.03, and 0.1 mg.kg-1, respectively; in contrast, DPCPX, when administered intravenously at the same doses, only increased urine flow by 0%, 18%, and 36%. The increases in urine flow induced by intraportal administration of DPCPX were abolished in rats with liver denervation. Intrahepatic infusion of adenosine significantly decreased urine flow and this response was abolished by intraportal administration of DPCPX. Neither intraportal nor intravenous administration of 3,7-dimethyl-1-propargylxanthine, a selective adenosine A2 receptor antagonist, showed significant influence on urine flow. Systemic arterial pressure, renal blood flow and glomerular filtration rate were unaltered by the administration of any of the drugs. In conclusion, intrahepatic adenosine A1 receptors are responsible for the adenosine-mediated hepatorenal reflex that regulates renal water and sodium excretion.
机译：以前的研究表明，肝内腺苷参与调节肾钠和水排泄的肝肾反射的激活。本研究旨在确定在该过程中牵涉哪种亚型的腺苷受体。在戊巴比妥麻醉的大鼠中监测平均动脉压，门静脉压和流量以及肾动脉流量。从膀胱收集尿液。选择性地输入8，环戊基1,3-二丙基黄嘌呤（DPCPX）腺苷A1受体拮抗剂，在0.01、0.03和0.1 mg.kg-的剂量下尿液流量分别增加了24％，89％和143％。 1，分别;相反，当以相同剂量静脉内给药时，DPCPX只会使尿流增加0％，18％和36％。在肝去神经支配的大鼠中，消除了因门静脉内施用DPCPX引起的尿流增加。肝内输注腺苷可显着减少尿流量，并且通过门内给予DPCPX可以消除这种反应。 3,7-二甲基-1-炔丙基黄嘌呤（一种选择性的腺苷A2受体拮抗剂）的经口内或静脉内给药均未显示对尿流的显着影响。全身性动脉压，肾血流量和肾小球滤过率均未因任何药物的使用而改变。总之，肝内腺苷A1受体负责调节腺苷介导的肝肾反射，调节肾水和钠排泄。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号