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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Behavioral and electroencephalographic manifestations of thioacetamide-induced encephalopathy in rats
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Behavioral and electroencephalographic manifestations of thioacetamide-induced encephalopathy in rats

机译：硫代乙酰胺诱发的大鼠脑病的行为和脑电图表现

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The aim of our study was to investigate the behavioral and electroencephalographic manifestations of thioaceta-mide-induced encephalopathy in rats. Male Wistar rats were divided among (i) control, saline-treated, and (ii) thioaceta-mide-treated groups (TAA 300 (300 mg/kg body mass); TAA 600 (600 mg/kg); and TAA 900 (900 mg/kg)). The daily dose of thioacetamide (300 mg/kg) was administered intraperitoneally once (TAA 300), twice (TAA 600), or 3 times (TAA 900), on subsequent days. Behavioral manifestations were determined at 0, 2, 4, 6, and 24 h, while electroencephalographic changes were recorded 22-24 h after the last dose. General motor activity and exploratory behavior, as well as head shake, auditory startle reflex, placement, and equlibrium tests were diminished in the TAA 600 and TAA 900 groups compared with the control, and were absent in the TAA 900 group 24 h after treatment. Corneal, withdrawal, grasping, and righting reflexes were significantly diminished in the TAA 900 group compared with the control. Mean electroencephalographic power spectra density was significantly higher in TAA 300 and TAA 600 and lower in the TAA 900 group by comparison with the control. Only a score of 3 (mean dominant frequency ≤ 7.3 Hz and d relative power ≥ 45%) was observed in the TAA 900 group. Thioacetamide induces encephalopathy in rats in a dose-dependent manner. A dose of 900 mg/kg TAA may be used as a suitable model of all stages of hepatic encephalopathy.
机译：我们的研究目的是调查硫代乙酰胺诱发的大鼠脑病的行为和脑电图表现。将雄性Wistar大鼠分为（i）对照组，生理盐水治疗组和（ii）硫代乙酰胺治疗组（TAA 300（300 mg / kg体重）; TAA 600（600 mg / kg）;和TAA 900（ 900 mg / kg）。随后几天，每天一次（TAA 300），两次（TAA 600）或3次（TAA 900）腹膜内给予硫代乙酰胺的每日剂量（300 mg / kg）。在0、2、4、6和24小时确定行为表现，而在最后一次给药后22-24小时记录脑电图变化。与对照组相比，TAA 600和TAA 900组的一般运动活动和探索行为以及头摇，听觉惊吓反射，放置和平衡测试均减少，而治疗后24小时在TAA 900组中则没有。与对照组相比，TAA 900组的角膜反射，缩回，抓握和扶正反射明显减少。与对照相比，平均脑电功率谱密度在TAA 300和TAA 600中显着较高，在TAA 900组中较低。 TAA 900组仅观察到3分（平均主频≤7.3 Hz，d相对功率≥45％）。硫代乙酰胺以剂量依赖性方式诱导大鼠脑病。 900 mg / kg TAA的剂量可用作肝性脑病所有阶段的合适模型。

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