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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats
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Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats

机译：印ne为基础的印a素A在四氯化碳中毒Wistar大鼠中的保肝活性

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摘要

The aim of this study was to investigate the hepatoprotective role of azadirachtin-A in carbon tetrachloride (CCl4) induced hepatotoxicity in rats. The group allotment for the animals used in the hepatoprotective study included a vehicle treatment group, CCl4 (1 mL·(kg body mass)-1) treatment group, silymarin (100 μg·(kg body mass)-1·day-1) + CCl4 treatment group, and groups treated with different doses of azadirachtin-A (100 or 200 μg·(kg body mass)-1·day-1) + CCl4. On the 9th day, blood was obtained for measuring the biochemical parameters, and liver tissue was obtained for pathological examination. The acute toxicity test with azadirachtin-A (500, 1000, or 2000 μg·(kg body mass)-1) indicated no mortality after 14 days of treatment; further, there was no change in behavior, food consumption, or organ mass. However with the higher dose, some hematological parameters showed changes. Hepatoprotective studies revealed that the CCl4 treatment group exhibited a decrease in total protein and albumin levels, whereas a significant increase in BUN, AST, ALT, and ALP levels were noticed compared with the vehicle-treated control, indicating that there was liver damage caused by CCl4. Histology and ultrastructure study confirmed that pretreatment with azadirachtin-A dose-dependently reduced hepatocellular necrosis and, therefore, protected the liver against toxicity caused by CCl4. The results from this study indicate that pretreatment with azadirachtin-A at the higher dose levels, moderately restores the rat liver to normal. This study confirms that azadirachtin-A possesses greater hepatoprotective action; however, the effective concentration needs to be determined.
机译：这项研究的目的是研究印za素-A在四氯化碳（CCl4）诱导的大鼠肝毒性中的肝保护作用。用于肝保护研究的动物的组分配包括媒介物治疗组，CCl4（1 mL·（kg体重）-1）治疗组，水飞蓟素（100μg·（kg体重）-1·day-1） + CCl4治疗组，以及用不同剂量的印za素A（100或200μg·（kg体重）-1·day-1）+ CCl4治疗的组。在第9天，获得血液用于测量生化参数，并且获得肝脏组织用于病理检查。用印za素-A（500、1000或2000μg·（kg体重）-1）进行的急性毒性试验表明，治疗14天后无死亡。此外，行为，食物消耗或器官质量没有变化。然而，随着剂量的增加，一些血液学参数显示出变化。肝脏保护研究显示，CCl4治疗组的总蛋白质和白蛋白水平降低，而与溶媒治疗的对照组相比，BUN，AST，ALT和ALP水平显着升高，表明存在肝脏损伤CCl4。组织学和超微结构研究证实，印a素A预处理可剂量依赖性地减少肝细胞坏死，从而保护肝脏免受CCl4引起的毒性。这项研究的结果表明，以较高剂量的印za素-A预处理可适度恢复大鼠肝脏的正常状态。该研究证实印za素A具有更大的肝保护作用。但是，需要确定有效浓度。

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