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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Characterization of the mechanisms involved in the gender differences in p-aminohippurate renal elimination in rats.
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Characterization of the mechanisms involved in the gender differences in p-aminohippurate renal elimination in rats.

机译：表征大鼠对氨基氨基嘌呤肾消除中性别差异的机制。

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摘要

Gender differences in the renal handling on drugs and toxins have received too little attention. In the present study, a variety of preparations were used to examine the basis for the greater effectiveness of the male kidneys in the elimination of p-aminohippurate (PAH) in rats. Renal clearance of PAH was significantly lower in female rats as consequence of its smaller filtered and secreted load. The gender difference in the filtered load may be accounted for the lower value of glomerular filtration rate (GFR) displayed by female rats as compared with males. The lower value of the renal blood flow observed in females might explain, at least in part, the decrease in the GFR and in the secreted load of PAH. In females, maximal uptake for PAH transport into renal basolateral membrane vesicles decreased to 52+/-9% (P < 0.05) and Michaelis-Menten constant for PAH uptake into renal brush border membrane vesicles was increased to 163+/-8% (P < 0.05). These changes might also explain the lower secreted load of PAH. The sex difference in the renal clearance of PAH was also evidenced by the reduced systemic clearance observed in female rats.
机译：肾脏在药物和毒素处理方面的性别差异受到的关注很少。在本研究中，使用了多种制剂来检查雄性肾脏在大鼠中消除对氨基马尿酸盐（PAH）的更大功效。雌性大鼠PAH的肾脏清除率明显降低，这是由于其过滤和分泌的负荷较小。过滤后的负荷中的性别差异可能是由于雌性大鼠显示的肾小球滤过率（GFR）与雄性相比较低。在女性中观察到的较低的肾血流量可能至少部分解释了GFR和PAH分泌负荷的降低。在女性中，PAH转运至肾基底外侧膜囊泡的最大摄入量下降至52 +/- 9％（P <0.05），而PAH摄入肾刷状缘膜囊泡的Michaelis-Menten常数增加至163 +/- 8％（ P <0.05）。这些变化也可以解释PAH分泌量较低的原因。雌性大鼠体内全身清除率的降低也证明了PAH肾脏清除率的性别差异。

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