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首页> 外文期刊>Forum of nutrition >Genetic Polymorphisms in Folate Metabolizing Enzymes and Risk of Gastroesophageal Cancers: A Potential Nutrient-Gene interaction in Cancer Development
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Genetic Polymorphisms in Folate Metabolizing Enzymes and Risk of Gastroesophageal Cancers: A Potential Nutrient-Gene interaction in Cancer Development

机译：叶酸代谢酶的遗传多态性和胃食管癌的风险：癌症发展中潜在的营养基因相互作用。

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摘要

Folate deficiency has been associated with certain types of human cancer. We therefore investigated the effects of genetic polymorphisms in Mate-metabolizing enzymes on the risk of developing gastroesophageal cancers in a Chinese population where folate deficiency is common. We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma. The polymorphisms modulate risk of these cancers associated with low folate status. Our results suggest that MTHFR and TS genotypes may be determinant of gastroesophageal cancers in this at-risk Chinese population.
机译：叶酸缺乏与某些类型的人类癌症有关。因此，我们研究了在叶酸缺乏常见的中国人群中，代谢伴侣酶中的遗传多态性对罹患胃食管癌风险的影响。我们发现亚甲基四氢叶酸还原酶（MTHFR）和胸苷酸合酶（TS）是参与叶酸和甲基代谢的两个关键酶的功能多态性，与食管鳞状细胞癌，胃card门癌和胰腺癌的风险增加显着相关。多态性调节这些与低叶酸状态有关的癌症的风险。我们的研究结果表明，MTHFR和TS基因型可能是这一高危中国人群胃食管癌的决定因素。

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