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Nutrition and Genome Health

机译：营养与基因组健康

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The link between genome damage and adverse health outcomes is compelling. There is increasing evidence indicating that genome instability, in the absence of overt exposure to genotoxins, is itself a sensitive marker of nutritional deficiency. We haveshown that above-average intake of certain micronutrients (i.e. calcium, vitamin E, retinol, folate, vitamin B12 and nicotinic acid) is associated with a reduced genome damage rate measured using the micronucleus assay. Genome health nutrigenomics is anemerging and important new field of nutritional science because it is increasingly evident that optimal concentration of micronutrients for the prevention of genome damage is dependent on genetic polymorphisms that alter the function of genes involved directly or indirectly in DNA repair and metabolism. Essentially this also means that the dietary 'nutriome' (i.e. nutrient profile and composition) recommendations should be matched to an individual's functional genome to optimise genome health maintenance. Development of functional foods and dietary patterns that are specifically designed to improve genome health maintenance in humans with specific genetic backgrounds are expected to provide an important contribution to a new health strategy based on the diagnosis and individualised nutritional treatment of genome instability (i.e. Genome Health Clinics).
机译：基因组损害与不良健康后果之间的联系令人信服。越来越多的证据表明，在没有明显暴露于基因毒素的情况下，基因组的不稳定性本身就是营养缺乏的敏感标志。我们已经表明，某些微量营养素（即钙，维生素E，视黄醇，叶酸，维生素B12和烟酸）的摄入量高于平均水平与使用微核分析法测得的基因组损伤率降低有关。基因组健康营养学正在兴起，并在营养学领域成为一个重要的新领域，因为越来越明显的是，用于预防基因组损伤的微量营养素的最佳浓度取决于遗传多态性，而遗传多态性改变了直接或间接参与DNA修复和代谢的基因的功能。从本质上讲，这还意味着饮食中的“营养素”（即营养成分和组成）建议应与个体的功能基因组相匹配，以优化基因组健康维护。专为改善具有特定遗传背景的人的基因组健康维护而设计的功能性食品和饮食模式有望为基于基因组不稳定性的诊断和个性化营养治疗的新健康策略（即基因组健康诊所）做出重要贡献。 ）。

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