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Development of Hypothalamic Neural Networks Controlling Appetite

机译：控制食欲的下丘脑神经网络的发展

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The hypothalamus plays an essential role in controlling appetite during adult life. It undergoes tremendous growth beginning early in gestation and continuing during the postnatal period. During this developmental period, a variety of processes shapethe hypothalamic nuclei involved in the control of eating. These include the birth of new cells that populate these areas (neurogenesis), the migration of these cells to their final destinations, selective neuronal death, and, finally, the development offunctional neural connections. Each of these developmental processes represents an important period of vulnerability during which alterations of the pre- (intrauterine) and early postnatal environments may have long-term and potentially irreversible consequences on hypothalamic development and function. Metabolic hormones, including the adipocyte-derived hormone leptin, have recently emerged as likely mediators of the environmental nutrient-sensing apparatus that directs hypothalamic programming.
机译：下丘脑在成年期的食欲控制中起着至关重要的作用。从妊娠早期开始一直持续到产后，它一直在经历巨大的增长。在这个发育时期，各种过程影响着控制饮食的下丘脑核。这些包括在这些区域中分布的新细胞的诞生（神经发生），这些细胞向其最终目的地的迁移，选择性神经元死亡以及功能神经连接的发展。这些发育过程中的每一个都代表着一个重要的脆弱时期，在此期间，子宫内（子宫内）和产后早期环境的改变可能会对下丘脑的发育和功能产生长期且潜在的不可逆转的后果。近年来，包括脂肪细胞源性激素瘦素在内的代谢激素已成为指导下丘脑程序设计的环境营养传感设备的可能介体。

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