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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Tempol improves vascular function in the mesenteric vascular bed of senescent rats.
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Tempol improves vascular function in the mesenteric vascular bed of senescent rats.

机译：Tempol改善衰老大鼠肠系膜血管床的血管功能。

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摘要

Ageing is associated with structural and functional alterations of the vasculature. The nature of age-related vascular disorders is not completely understood. Oxidative stress is hypothesized to play a crucial role in the pathophysiology of vascular complications. We investigated the effects of chronic treatment with the superoxide dismutase mimetic tempol (4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl) on vascular function in the mesenteric vasculature of aged rats. Young (3 weeks) and old (40 weeks) Sprague–Dawley rats were treated with tempol (1 mM in drinking water) or vehicle for 3 weeks. Arterial blood pressure was slightly, but significantly, higher in old than in young rats. Tempol had no effect on arterial blood pressure. The vasoconstrictor responses to norepinephrine (NE) and serotonin (5-HT) were exaggerated in the mesenteric vascular bed (MVB) removed from old rats. Vasodilator responses to acetylcholine (ACh), papaverine (PPV), and isoprenaline (ISO) were reduced in the MVB of old rats in comparison with young rats. Chronic treatment of old rats with tempol normalized their responses to NE and 5-HT. The dilator responses to ACh, PPV, and ISO were similar between old rats receiving tempol and young rats. The present findings suggest that oxidative stress contributes to vascular dysfunction in the mesentery of old rats. The vasculoprotective effects of tempol remain to be elucidated.
机译：衰老与脉管系统的结构和功能改变有关。与年龄有关的血管疾病的性质尚未完全了解。假设氧化应激在血管并发症的病理生理中起关键作用。我们调查了超氧化物歧化酶模拟tempol（4-羟基-2,2,6,6-四甲基哌啶氧基）对老年大鼠肠系膜脉管系统血管功能的慢性治疗作用。幼鼠（3周）和老年（40周）大鼠用tempol（饮用水中1 mM）或媒介物治疗3周。老年大鼠的动脉血压略高，但显着高于年轻大鼠。 Tempol对动脉血压没有影响。从老大鼠取出的肠系膜血管床（MVB）中，对去甲肾上腺素（NE）和5-羟色胺（5-HT）的血管收缩反应被夸大了。与年轻大鼠相比，老年大鼠的MVB对乙酰胆碱（ACh），罂粟碱（PPV）和异丙肾上腺素（ISO）的血管舒张反应降低。用tempol长期治疗老年大鼠可正常化其对NE和5-HT的反应。接受tempol的老年大鼠和年轻大鼠对ACh，PPV和ISO的扩张剂反应相似。目前的发现表明，氧化应激是老年大鼠肠系膜中血管功能障碍的原因。 tempol的血管保护作用仍有待阐明。

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