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首页> 外文期刊>Fish Physiology and Biochemistry >Inhibition of HPI axis response to stress in gilthead sea bream (Sparus aurata) with physiological plasma levels of cortisol
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Inhibition of HPI axis response to stress in gilthead sea bream (Sparus aurata) with physiological plasma levels of cortisol

机译：生理血浆皮质醇水平抑制金头鲷（Sparus aurata）对HPI轴的应激反应

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摘要

This study investigates the effect of corticosteroid (cortisol) administration on the stress response of the gilthead sea bream Sparus aurata subjected to a 48 h confinement. The effect of (in-vitro and in-vivo) cortisol administration on the in-vitro ACTH sensitivity of the interrenal tissue; the plasma levels and tissue concentration of cortisol; and the plasma levels of ACTH, #alpha#-MSH, #beta#-endorphin and glucose were determined. Confinement caused a transient and concomitant increase in plasma cortisol and ACTH levels. However, in cortisol-fed fish the plasma ACTH levels were lower, indicating a suppresion of the ACTH release from the corticotropes by cortisol. In contrast to the activation of the corticotropes, the levels of plasma melanotrope derived peptides were not affected. In contrast to the activation of the corticotropes, the levels of plasma melanotrope derived peptides were not affected. In spite of the fact that interrenal cells of cortisol-fed gilthead sea bream released less cortisol than controls, the interrenal sensitivity to ACTH was not affected by in-vivo and in-vitro cortisol administration. This suggests that the interrenal sensitivity to ACTH in stressed (confinement sea bream is probably not regulated by #alpha#-MSH, N-ac-#beta#-END, or by cortisol. Thus, in gilthead sea bream the interrenal sensitivity to ACTH could be regulated at the hypothalamus and/or pituitary and communicated via circulating ACTH levels.
机译：这项研究调查了皮质类固醇（皮质醇）施用对禁食48 h的金头鲷鱼Sparus aurata应激反应的影响。 （体外和体内）皮质醇给药对肾间组织体外ACTH敏感性的影响;皮质醇的血浆水平和组织浓度;测定血浆ACTH，＃alpha＃-MSH，＃beta＃-内啡肽和葡萄糖水平。限制引起血浆皮质醇和ACTH水平的短暂而同时的增加。但是，在以皮质醇喂养的鱼中血浆ACTH水平较低，表明皮质醇可抑制促肾上腺皮质激素释放ACTH。与促肾上腺皮质激素的激活相反，血浆黑素体衍生肽的水平不受影响。与促肾上腺皮质激素的激活相反，血浆黑素体衍生肽的水平不受影响。尽管饲喂皮质醇的金头鲷的肾间细胞释放的皮质醇少于对照组，但肾内对ACTH的敏感性不受体内和体外皮质醇给药的影响。这表明在紧张（ine鱼）中，肾间质对ACTH的敏感性可能不受＃alpha＃-MSH，N-ac-＃beta＃-END或皮质醇的调节。因此，在金头鲷中，肾间质对ACTH的敏感性可以在下丘脑和/或垂体调节，并通过循环ACTH水平进行沟通。

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