Women and the management of acute coronary syndrome

OstadalP.; OstadalB.

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Women and the management of acute coronary syndrome

机译：妇女与急性冠脉综合征的管理

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Coronary heart disease (CHD) is the leading cause of morbidity and mortality in both men and women in the developed countries. despite this fact, females are still under-represented in the majority of clinical trials. At the present time, only limited evidence is available with respect to the female-specific aspects of pathogenesis, management, and outcomes in acute coronary syndrome (ACS). Women less frequently undergo coronary intervention, and a lower proportion of women receive evidence-based pharmacotherapy, compared with men. It has been shown that women benefit from an invasive approach and coronary intervention in ACS as much as men, despite their advanced age and higher rate of bleeding complications. Also, administration of beta-blockers, ACE-inhibitors, and intensive statin therapy is associated with a comparable reduction of cardiovascular event rates in women and men. On the other hand, women may profit less than men from fibri-nolytic or glycoprotein IIb/IIIa inhibitor therapy. Both sexes benefit equally from aspirin therapy, whereas contradictory data are available on the efficacy of clopidogrel in women. There is an urgent need for intensive research in the development of female-specific therapeutic strategy in ACS, even though the detailed mechanisms of sex differences are still unknown.

机译：冠心病（CHD）是发达国家男女的发病率和死亡率的主要原因。尽管有这个事实，但大多数临床试验中女性的代表性仍然不足。目前，关于急性冠状动脉综合征（ACS）的发病机制，治疗和预后方面的女性特异性方面，仅有有限的证据。与男性相比，女性接受冠脉介入治疗的频率降低，女性接受循证药物治疗的比例更低。研究表明，尽管女性高龄且出血并发症发生率较高，但与男性一样，女性从侵入性治疗和冠状动脉介入治疗中受益的程度与男性相同。同样，在男性和女性中，使用β受体阻滞剂，ACEI抑制剂和强化他汀类药物治疗与降低心血管事件发生率相关。另一方面，女性从纤溶酶或糖蛋白IIb / IIIa抑制剂治疗中获得的利润可能比男性少。男女平等地从阿司匹林治疗中受益，而关于氯吡格雷在女性中的疗效却存在矛盾的数据。尽管性别差异的详细机制仍然未知，但迫切需要对ACS的女性特异性治疗策略进行深入研究。

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《Canadian Journal of Physiology and Pharmacology》 |2012年第9期|共9页
作者
OstadalP.; OstadalB.;
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正文语种 eng
中图分类药理学;
关键词
Acute coronary syndrome; Coronary revascularization; Pharmacotherapy; Sex differences; Women;

机译：急性冠状动脉综合征;冠脉血运重建;药物治疗;性别差异;妇女;

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1. 2013 ACCF/AHA Key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes and coronary artery disease: A report of the American college of cardiology foundation/American Heart Association Task force on Clinical Data Standards (Writing committee to develop acute coronary syndromes and coronary artery disease clinical data standards) [J] . CannonC.P., BrindisR.G., ChaitmanB.R., Circulation: An Official Journal of the American Heart Association . 2013,第9期

机译：2013 ACCF / AHA衡量急性冠脉综合征和冠心病患者的临床管理和结局的关键数据要素和定义：美国心脏病学会基金会/美国心脏协会临床数据标准工作组的报告（制定急性冠状动脉综合征和冠状动脉疾病的临床数据标准）
2. Guidelines in review: Comparison of the 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes and the 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J] . Shane P. Prejean, Munaib Din, Eliana Reyes, Journal of nuclear cardiology: official publication of the American Society of Nuclear Cardiology . 2018,第3期

机译：审查指南：2014年AHA / ACC管理指南的非ST-EXPRATION急性冠状动脉综合征患者的指南和2015年ESC患者患者急性冠状动脉综合征管理指南，患者在没有持续存在的ST段仰角升高
3. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) [J] . Roffi Marco, Patrono Carlo, Collet Jean-Philippe, European Heart Journal: The Journal of the European Society of Cardiology . 2016,第3期

机译：欧洲心脏病学会（ESC）2015年ESC持续性ST段抬高不持续的患者急性冠脉综合征的治疗指南急性不持续性ST段抬高的患者急性冠状动脉综合征的管理工作组
4. Management in Acute Coronary Syndrome with Severe Heart Failure: Supportive Treatment with Intraaortic Balloon Pump [C] . Z. Mitrev, A. Vasileva, I. Milev, International Congress on Coronary Artery Disease . 2003

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5. Clarifying the Optimal Management Strategy for Patients with Possible Acute Coronary Syndrome with Intermediate Stenosis and High-Risk Plaque Morphology on Coronary Computed Tomographic Angiography [D] . Dwyer, Stephanie M. 2019

机译：明确可能的急性冠脉综合征合并中度狭窄和高风险斑块形态的冠状动脉计算机断层扫描血管造影的最佳管理策略
6. Improving the management of non-ST elevation acute coronary syndromes: systematic evaluation of a quality improvement programme European QUality Improvement Programme for Acute Coronary Syndrome: The EQUIP-ACS project protocol and design [O] . Marcus D Flather, Jean Booth, Daphne Babalis, 2010

机译：改善非ST段抬高的急性冠状动脉综合征的管理：质量改善计划的系统评估欧洲急性冠脉综合征的质量改善计划：EQUIP-ACS项目方案和设计
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Women and the management of acute coronary syndrome

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