LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis

Ding Zufeng; Liu Shijie; Wang Xianwei; Dai Yao; Khaidakov Magomed; Romeo Francesco; Mehta Jawahar L.

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LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis

机译：LOX-1，动脉粥样硬化中的氧化应激，mtDNA损伤，自噬和免疫反应

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As a major receptor for oxidized low density lipoprotein (ox-LDL), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in many pathophysiological events, including endothelial cell dysfunction and smooth muscle cell growth, as well as monocyte migration and transformation into foam cells, which are present in atherosclerosis and myocardial ischemia. Excessive production of reactive oxygen species (ROS) increases LOX-1 expression, induces mitochondrial DNA damage, and activates autophagy. Damaged mitochondrial DNA that escapes from autophagy induces an inflammatory response. This paper reviews the potential link between LOX-1, mitochondrial DNA damage, autophagy, and immune response in atherosclerosis.

机译：作为氧化型低密度脂蛋白（ox-LDL）的主要受体，凝集素样氧化型低密度脂蛋白受体1（LOX-1）在许多病理生理事件中均被上调，包括内皮细胞功能障碍和平滑肌细胞生长单核细胞迁移并转化为泡沫细胞，而泡沫细胞存在于动脉粥样硬化和心肌缺血中。过量产生活性氧（ROS）会增加LOX-1的表达，诱导线粒体DNA损伤并激活自噬。逃脱自噬的线粒体DNA受损会引起炎症反应。本文综述了动脉粥样硬化中LOX-1，线粒体DNA损伤，自噬和免疫反应之间的潜在联系。

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《Canadian Journal of Physiology and Pharmacology》 |2014年第7期|共7页
作者
Ding Zufeng; Liu Shijie; Wang Xianwei; Dai Yao; Khaidakov Magomed; Romeo Francesco; Mehta Jawahar L.;
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正文语种 eng
中图分类药理学;
关键词
LOX-1; mitochondrial DNA; autophagy; immunity; atherosclerosis; reactive oxygen species; oxidized LDL;

机译：LOX-1;线粒体DNA;自噬;免疫;动脉粥样硬化;活性氧;氧化LDL;

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专利

1. LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis [J] . Ding Zufeng, Liu Shijie, Wang Xianwei, Canadian Journal of Physiology and Pharmacology . 2014,第7期

机译：LOX-1，动脉粥样硬化中的氧化应激，mtDNA损伤，自噬和免疫反应
2. Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress [J] . Umar Sheikh Ahmad, Tasduq Sheikh Abdullah RSC Advances . 2020,第60期

机译：在紫外线诱导的皮肤损伤中集成DNA损伤响应和自噬信号轴：保护细胞免受遗传毒性应激的阳性关联
3. Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress [J] . Sheikh Ahmad Umar, Sheikh Abdullah Tasduq RSC Advances . 2020,第60期

机译：在紫外线诱导的皮肤损伤中集成DNA损伤响应和自噬信号轴：保护细胞免受遗传毒性应激的阳性关联
4. Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Obesity, Diabetes, and other Risk Factors for Atherosclerosis [C] . G.L. Milne, J.D. Brooks, H.L. Borntrager, International Society for Free Radical Research . 2006

机译：异丙醇和相关化合物作为肥胖，糖尿病和动脉粥样硬化的其他危险因素的氧化剂应激的标记和介质
5. The critical role of lectin-like oxidized-low density lipoprotein receptor-1 (LOX-1) in atherosclerosis and related pathological processes. [D] . Chen, Jiawei. 2005

机译：凝集素样氧化低密度脂蛋白受体1（LOX-1）在动脉粥样硬化和相关病理过程中的关键作用。
6. Oxidant stress in mitochondrial DNA damage autophagy and inflammation in atherosclerosis [O] . Zufeng Ding, Shijie Liu, Xianwei Wang, -1

机译：线粒体DNA损伤中的氧化应激动脉粥样硬化中的自噬和炎症
7. Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis [O] . Zufeng Ding, Shijie Liu, Xianwei Wang, 2013

机译：线粒体DNA损伤的氧化胁迫，动脉粥样硬化中的自噬和炎症

LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis

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