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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of morphine withdrawal on catecholaminergic neurons on heart right ventricle; implication of dopamine receptors.
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Effects of morphine withdrawal on catecholaminergic neurons on heart right ventricle; implication of dopamine receptors.

机译：吗啡戒断对心脏右心室儿茶酚胺能神经元的影响;多巴胺受体的含义。

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摘要

The purpose of our study was to examine the effects of D1-and D2-dopamine receptors blockade on the changes in the ventricular content of catecholamines in rats withdrawn from morphine. Rats were given morphine by subcutaneous (s.c.) implantation of morphine pellets for 5 days. On the eighth day, morphine withdrawal was induced by s.c. administration of naloxone (1 mg/kg), and rats were killed 30 min later. Pretreatment with SCH 23390 (dopamine D1, D5 receptor antagonist) 15 min prior to naloxone administration suppressed some the behavioural signs of morphine withdrawal, whereas eticlopride (dopamine D2, D3, D4 receptor antagonist) did not. In addition, biochemical analysis indicate that SCH 23390 completely abolished the withdrawal-induced increase in noradrenaline and dopamine turnover in the right ventricle. By contrast, eticlopride did not block the hyperactivity of catecholaminergic neurons in the heart during morphine withdrawal. These data suggest that the hyperactivity of catecholaminergic neurons in the heart during morphine withdrawal is dependent upon D1 dopamine receptor activation. In addition, our results exclude the involvement of D2 dopamine receptors.
机译：本研究的目的是研究D1和D2多巴胺受体阻滞剂对吗啡撤离大鼠的儿茶酚胺心室含量变化的影响。通过皮下（s.c.）吗啡药丸植入大鼠，给予吗啡5天。在第八天，皮下注射吗啡戒断。给予纳洛酮（1 mg / kg），并于30分钟后处死大鼠。纳洛酮给药前15分钟用SCH 23390（多巴胺D1，D5受体拮抗剂）进行预处理可抑制吗啡戒断的某些行为征象，而艾替普利（多巴胺D2，D3，D4受体拮抗剂）则没有。此外，生化分析表明，SCH 23390完全消除了右心室中撤药引起的去甲肾上腺素和多巴胺更新的增加。相反，艾替洛必利在吗啡戒断期间并未阻止心脏中儿茶酚胺能神经元的过度活动。这些数据表明吗啡戒断期间心脏中儿茶酚胺能神经元的过度活动取决于D1多巴胺受体的激活。此外，我们的结果排除了D2多巴胺受体的参与。

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