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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of PACAP(1-27) on the canine endocrine pancreas in vivo: interaction with cholinergic mechanism.
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Effects of PACAP(1-27) on the canine endocrine pancreas in vivo: interaction with cholinergic mechanism.

机译：PACAP（1-27）在体内对犬内分泌胰腺的影响：与胆碱能机制的相互作用。

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摘要

The aim of the present study was to characterize the effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the endocrine pancreas in anesthetized dogs. PACAP(1-27) and a PACAP receptor (PAC(1)) blocker, PACAP(6-27), were locally administered to the pancreas. PACAP(1-27) (0.005-5 microg) increased basal insulin and glucagon secretion in a dose-dependent manner. PACAP(6-27) (200 microg) blocked the glucagon response to PACAP(1-27) (0.5 microg) by about 80%, while the insulin response remained unchanged. With a higher dose of PACAP(6-27) (500 microg), both responses to PACAP(1-27) were inhibited by more than 80%. In the presence of atropine with an equivalent dose (128.2 microg) of PACAP(6-27) (500 microg) on a molar basis, the insulin response to PACAP(1-27) was diminished by about 20%, while the glucagon response was enhanced by about 80%. The PACAP(1-27)-induced increase in pancreatic venous blood flow was blocked by PACAP(6-27) but not by atropine. The study suggests that the endocrine secretagogue effect of PACAP(1-27) is primarily mediated by the PAC(1) receptor, and that PACAP(1-27) may interact with muscarinic receptor function in PACAP-induced insulin and glucagon secretion in the canine pancreas in vivo.
机译：本研究的目的是表征垂体腺苷酸环化酶激活多肽（PACAP）对麻醉犬内分泌胰腺的影响。将PACAP（1-27）和PACAP受体（PAC（1））阻滞剂PACAP（6-27）局部给药于胰腺。 PACAP（1-27）（0.005-5 microg）以剂量依赖性方式增加基础胰岛素和胰高血糖素的分泌。 PACAP（6-27）（200微克）阻断胰高血糖素对PACAP（1-27）（0.5微克）的反应约80％，而胰岛素反应保持不变。使用较高剂量的PACAP（6-27）（500微克），对PACAP（1-27）的两种反应均被抑制80％以上。在阿托品存在的情况下，以摩尔计当量（128.2微克）的PACAP（6-27）（500微克），对PACAP（1-27）的胰岛素反应降低约20％，而胰高血糖素反应提升了约80％ PACAP（6-27）阻止了PACAP（1-27）诱导的胰腺静脉血流量增加，但阿托品却没有。该研究表明，PACAP（1-27）的内分泌促分泌作用主要是由PAC（1）受体介导的，并且PACAP（1-27）可能与毒蕈碱受体功能在PACAP诱导的胰岛素和胰高血糖素分泌中相互作用。犬胰腺体内。

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