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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Role of endothelins in congestive heart failure.
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Role of endothelins in congestive heart failure.

机译：内皮素在充血性心力衰竭中的作用。

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摘要

Despite major advances in conventional medical therapy, patients with heart failure continue to experience significant morbidity and mortality. Endothelin-1 (ET-1) is a potent vasocontrictor and mitogenic peptide that is activated in heart failure. There is increasing experimental and clinical evidence in support of an important role of ET-1 in the pathophysiology of heart failure. Manipulation of the activity of ET-1, especially using endothelin receptor blockers, has allowed for the further elucidation of the role of this neurohormonal system and development of novel therapeutic strategies in heart failure. Published clinical studies of these agents to date have involved relatively small numbers of patients with severe heart failure, followed for a relatively short period of time, and have mainly examined surrogate endpoints. Large-scale trials that address to hard clinical outcomes are ongoing and their results forthcoming. A key question that remains concerns whether selective ETA or dual ETA-ETB receptor blockade will be more effective.
机译：尽管常规药物治疗取得了重大进展，但心力衰竭患者仍继续出现明显的发病率和死亡率。内皮素-1（ET-1）是一种有效的血管收缩药和促有丝分裂肽，可在心力衰竭时被激活。越来越多的实验和临床证据支持ET-1在心力衰竭的病理生理中的重要作用。 ET-1活性的操纵，尤其是使用内皮素受体阻滞剂，已经可以进一步阐明这种神经激素系统的作用以及开发新的治疗心力衰竭的策略。迄今为止，已发表的有关这些药物的临床研究涉及相对少量的严重心力衰竭患者，随访时间相对较短，并且主要检查了替代终点。旨在解决临床难题的大规模试验正在进行中，其结果即将发布。仍然存在的一个关键问题是选择性ETA或双重ETA-ETB受体阻滞是否会更有效。

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