...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Comparative effects of tamoxifen and angiotensin II type-1 receptor antagonist therapy on the hemodynamic profile of the ovariectomized female rat.
【24h】

Comparative effects of tamoxifen and angiotensin II type-1 receptor antagonist therapy on the hemodynamic profile of the ovariectomized female rat.

机译：他莫昔芬和血管紧张素II 1型受体拮抗剂治疗对去卵巢雌性大鼠血液动力学特征的比较作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hormonal replacement therapy (HRT) has failed to provide a cardioprotective action in postmenopausal women, and thus alternative pharmacological approaches are required. The present study examined the therapeutic potential of the partial estrogen receptor agonist tamoxifen and the angiotensin II type-1 receptor antagonist irbesartan on the hemodynamic profile of ovariectomized (OVX) female Sprague-Dawley rats (9-11 weeks). Three weeks following ovariectomy, uterine atrophy was evident and body weight was increased as compared with sham-operated animals. Left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and mean arterial pressure (MAP) were significantly increased in the OVX rats as compared with sham rats. One week following ovariectomy, rats were treated with either tamoxifen (10 mg kg-1 day-1) or irbesartan (40 mg kg-1 day-1) for a period of 2 weeks. The administration of tamoxifen to OVX rats partially reversed uterine atrophy and prevented body weight gain,albeit body weight remained significantly lower than in sham-operated animals. LVSP and LVEDP were normalized in the tamoxifen-treated OVX rats, whereas MAP remained elevated. Irbesartan partially reduced the body weight gain of the OVX rats and did not influence uterine atrophy. LVSP and MAP were normalized in irbesartan-treated OVX rats, whereas LVEDP remained elevated. These data demonstrate that irbesartan rather than tamoxifen was efficacious in normalizing MAP in the OVX rats without a secondary effect on the uterus.
机译：激素替代疗法（HRT）无法为绝经后妇女提供心脏保护作用，因此需要其他药理方法。本研究检查了部分雌激素受体激动剂他莫昔芬和血管紧张素II 1型受体拮抗剂厄贝沙坦对去卵巢（OVX）雌性Sprague-Dawley大鼠（9-11周）血液动力学特征的治疗潜力。与假手术的动物相比，卵巢切除术后三周，子宫明显萎缩，体重增加。与假手术大鼠相比，OVX大鼠的左心室收缩压（LVSP），左心室舒张末期压力（LVEDP）和平均动脉压（MAP）显着增加。卵巢切除术后一周，大鼠用他莫昔芬（10 mg kg-1 day-1）或厄贝沙坦（40 mg kg-1 day-1）治疗2周。他莫昔芬对OVX大鼠的给药可部分逆转子宫萎缩并预防体重增加，尽管其体重仍显着低于假手术动物。在他莫昔芬治疗的OVX大鼠中LVSP和LVEDP正常化，而MAP仍然升高。厄贝沙坦可部分降低OVX大鼠的体重，并且不影响子宫萎缩。在厄贝沙坦治疗的OVX大鼠中，LVSP和MAP正常化，而LVEDP仍然升高。这些数据表明，厄贝沙坦而不是他莫昔芬可有效地使OVX大鼠的MAP正常化，而对子宫没有辅助作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号