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Effect of Inorganic Mercury on Hematological and Antioxidant Parameters on Olive Flounder Paralichthys olivaceus

机译:无机汞对橄榄比目鱼的免疫学和血液学参数的影响

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The effects of inorganic mercury on hematological parameters and hepatic oxidative stress enzyme activity were studied in olive flounder Paralichthys olivaceus. Fish were injected twice intraperitoneally with mercuric chloride (2, 4, or 8 mg Hg/kg BW). The major hematological findings were significant decreases in the red blood cell count, hematocrit value, and hemoglobin level in olive flounder exposed to 8 mg Hg/kg BW. Remarkably low levels of calcium and chloride, and reduced osmolality, were alsoobserved at 8 mg Hg/kg BW. In hepatic tissue, significant increases in glutathione peroxidase and catalase activity were observed above 4 mg Hg/kg BW Inorganic mercury also increased glutathione S-transferase and glutathione reductase activity at 8 mg Hg/ kg BW in hepatic tissue. The present findings suggest that exposure to a low concentration (>4 mg Hg/kg BW) of inorganic mercury can cause significant changes in hematological and antioxidant parameters.
机译:在橄榄比目鱼Paraliichthys olivaceus中研究了无机汞对血液学参数和肝氧化应激酶活性的影响。鱼腹膜内注射氯化汞两次(2、4或8 mg Hg / kg BW)。主要的血液学发现是暴露于8 mg Hg / kg BW的比目鱼的红细胞计数,血细胞比容值和血红蛋白水平显着下降。在8 mg Hg / kg BW时也观察到钙和氯化物的含量非常低,并且渗透压降低。在肝组织中,高于4 mg Hg / kg BW时,观察到谷胱甘肽过氧化物酶和过氧化氢酶活性显着增加。在肝组织中,8 mg Hg / kg BW时,无机汞还增加了谷胱甘肽S-转移酶和谷胱甘肽还原酶活性。目前的发现表明,暴露于低浓度(> 4 mg Hg / kg BW)的无机汞会导致血液学和抗氧化剂参数发生重大变化。

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