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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Activities of antioxidant enzymes in two stages of pathology development in sucrose-fed rats.
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Activities of antioxidant enzymes in two stages of pathology development in sucrose-fed rats.

机译:蔗糖喂养的大鼠在病理发展的两个阶段中抗氧化酶的活性。

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The activities of catalase in liver, heart and kidney as well as glutathione peroxidase and superoxide dismutase in liver, heart, kidney, and serum from hypertriglyceridemic and hypertensive female and male rats were measured at 3 and 8 months of daily administration of sucrose in their drinking water. This treatment induces high levels of serum triglycerides, central obesity, moderate hypertension, hyperinsulinemia, and an increase in lipoper oxida tion, among other alterations. The experimental periods were chosen on the basis of previous observations: at 3 months the level of serum triglycerides increases significantly above the normal value and remains without major changes thereafter, but the blood pressure only rises significantly at about 4 months in males and 5 months in females. So, at 8 months the rats have been subjected to abnormal conditions for 3–4 months. The effect of these and the influence of sex on levels of antioxidant enzymes were investigated. Both factors, sucrose treatmentand sex, were conducive to significant changes in those variables.
机译:在每天饮用蔗糖的3和8个月中,测定高甘油三酸酯血症和高血压雌性和雄性大鼠肝脏,心脏和肾脏中过氧化氢酶的活性,以及​​肝脏,心脏,肾脏和血清中谷胱甘肽过氧化物酶和超氧化物歧化酶的活性水。这种治疗方法可引起高水平的血清甘油三酸酯,中枢性肥胖,中​​度高血压,高胰岛素血症以及唇oper肉氧化的增加等。根据之前的观察结果选择实验时期:在3个月时,血清甘油三酸酯的水平显着高于正常值,此后保持较大的变化,但是男性中血压仅在约4个月时显着升高,而在5个月中血压仅显着升高。女性。因此,在8个月时,大鼠经历了3到4个月的异常状况。研究了这些影响以及性别对抗氧化酶水平的影响。蔗糖处理和性别这两个因素都有助于这些变量的显着变化。

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