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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Thermoregulatory, motor, behavioural, and nociceptive responses of rats to 3 long-acting neuroleptics.
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Thermoregulatory, motor, behavioural, and nociceptive responses of rats to 3 long-acting neuroleptics.

机译：大鼠对3种长效抗精神病药的温度调节，运动，行为和伤害感受反应。

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摘要

We investigated physiological effects of intramuscular injections of the following 3 long-acting neuroleptics commonly used in wildlife management: haloperidol (0.05, 0.1, and 0.5 mg/kg body mass), zuclopenthixol acetate (0.5, 1, and 5 mg/kg), and perphenazine enanthate (1, 3, and 10 mg/kg), in a rat model. Body temperature and cage activity were measured by intra-abdominal telemeters. Nociceptive responses were assessed by challenges to noxious heat and pressure. Haloperidol (0.5 mg/kg) produced a significant nocturnal hypothermia (p < 0.05) and decreased nighttime cage activity and food intake. Zuclopenthixol (5 mg/kg) significantly decreased nighttime body temperature and cage activity and, at 1 mg/kg and 5 mg/kg, significantly decreased food intake 5-17 h after injection (p < 0.05). Perphenazine (10 mg/kg) significantly decreased nighttime body temperature and cage activity and, at all doses, significantly decreased food intake 5-17 h after injection (p < 0.05). Significant analgesic activity was evident in rats given 5 mg/kg zuclopenthixol up to 40 h after injection, and 10 mg/kg perphenazine from 48 to 96 h after injection (p < 0.0001). Zuclopenthixol (5 mg/kg) and perphenazine (10 mg/kg) had significant antihyperalgesic activities at 16 h postinjection and 24-48 h postinjection, respectively (p < 0.0001). Haloperidol had no significant antinociceptive activity at doses tested. Motor function was impaired in rats given 0.5 mg/kg haloperidol, 5 mg/kg zuclopenthixol and 10 mg/kg perphenazine. Effects of long-acting neuroleptics on body temperature, feeding, and activity were short-lasted and should not preclude their use in wildlife. Antinociceptive actions were longer-lasting, but were nonspecific, and we recommend additional analgesics for painful procedures during wildlife management.
机译：我们调查了以下3种常用于野生动植物管理的长效抗精神病药的肌肉注射的生理效应：氟哌啶醇（0.05、0.1和0.5 mg / kg体重），盐酸左氯噻酚（0.5、1和5 mg / kg），和大鼠模型中的奋乃静庚酸酯（1、3和10 mg / kg）。体温和笼活动度通过腹内遥测仪测量。通过对有毒的热量和压力的挑战来评估伤害感受反应。氟哌啶醇（0.5 mg / kg）产生明显的夜间体温过低（p <0.05），并降低了夜间笼养活动和食物摄入量。 Zuclopenthixol（5 mg / kg）可以显着降低夜间体温和笼活动，并且在1 mg / kg和5 mg / kg时，注射后5-17 h的食物摄入量显着降低（p <0.05）。奋乃静（10 mg / kg）显着降低了夜间体温和笼活动，并且在所有剂量下，注射后5-17 h的食物摄入均显着降低（p <0.05）。在注射后40小时内给予5 mg / kg zuclopenthixol和在注射后48至96 h给予10 mg / kg奋乃静的大鼠均具有明显的镇痛活性（p <0.0001）。 Zuclopenthixol（5 mg / kg）和奋乃静（10 mg / kg）分别在注射后16 h和注射后24-48 h具有明显的抗痛觉过敏活性（p <0.0001）。氟哌啶醇在所测试的剂量下没有明显的抗伤害感受活性。给予0.5 mg / kg氟哌啶醇，5 mg / kg左氯哌丁醇和10 mg / kg奋乃静的大鼠运动功能受损。长效抗精神病药对体温，摄食和活动的影响持续时间很短，不应排除在野生动植物中的使用。抗伤害性作用持续时间较长，但没有特异性，我们建议在野生动植物管理过程中使用其他镇痛剂进行镇痛。

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