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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Asynchronous calcium waves in smooth muscle cells.
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Asynchronous calcium waves in smooth muscle cells.

机译:平滑肌细胞中的异步钙波。

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摘要

Asynchronous Ca2+ waves or wave-like [Ca2+]i oscillations constitute a specialized form of agonist-induced Ca2+ signaling that is observed in a variety of smooth muscle cell types. Functionally, it is involved in the contractile regulation of the smooth muscle cells as it signals for tonic contraction in certain smooth muscle cells while causing relaxation in others. Mechanistically, repetitive Ca2+ waves are produced by repetitive cycles of sarcoplasmic reticulum Ca2+ release followed by Ca2+ uptake. Plasmalemmal Ca2+ entry mechanisms are important for providing the additional Ca2+ necessary to maintain proper refilling of the sarcoplasmic reticulum Ca2+ store and support ongoing Ca2+ waves. In this paper, we will review the phenomenon of asynchronous Ca2+ waves in smooth muscle and discuss the scientific and clinical significance of this new understanding.
机译:异步Ca2 +波或波状[Ca2 +] i振荡构成激动剂诱导的Ca2 +信号转导的一种特殊形式,这种信号在各种平滑肌细胞类型中均可观察到。从功能上讲,它参与了平滑肌细胞的收缩调节,因为它在某些平滑肌细胞中发出了强直收缩的信号,而在其他平滑肌细胞中引起了松弛。从机制上讲,重复的Ca2 +波是由肌浆网Ca2 +释放后再吸收Ca2 +的重复循环产生的。血浆Ca2 +进入机制对于提供额外的Ca2 +至关重要,以维持肌浆网Ca2 +储库的适当补充并支持持续的Ca2 +波。在本文中,我们将回顾平滑肌中异步Ca2 +波的现象,并讨论这种新认识的科学和临床意义。

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