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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy.
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Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy.

机译：腔内施用亚硝酸钠作为勃起药物疗法。

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摘要

It has been reported that sodium nitrite (NaNO2) can act as a storage form of nitric oxide (NO) that can have beneficial pharmacologic actions. The present study was undertaken to investigate the effects of NaNO2 on erectile function in the rat. The intracavernosal (i.c.) injection of NaNO2 produced dose-related increases in i.c. pressure and decreases in systemic arterial pressure. NaNO2 was 1000-fold less potent than sodium nitroprusside in increasing i.c. pressure. Increases in i.c. pressure in response to NaNO2 were attenuated by the nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME). The increases in i.c. pressure in response to NaNO2 were not altered by the xanthine oxidoreductase inhibitor allopurinol. The decreases in systemic arterial pressure in response to i.c. injections of NaNO2 were attenuated by allopurinol and were either unchanged or increased by L-NAME. These data suggest that NaNO2 is converted to vasoactive NO in the corpora cavernosum and systemic vascular bed of the rat by different mechanisms. The present data suggest that the conversion of NaNO2 to vasoactive NO is mediated by NOS in the corpora cavernosum and by xanthine oxidoreductase in the systemic vascular bed of the rat. These data show NaNO2 can serve as a NO donor that increases erectile activity in the rat.
机译：据报道，亚硝酸钠（NaNO2）可以作为一氧化氮（NO）的储存形式，具有有益的药理作用。进行本研究以研究NaNO 2对大鼠勃起功能的影响。腔内（Na.2）的腔内注射在I.c中产生剂量相关的增加。压力和全身动脉压降低。在增加i.c.方面，NaNO2的效力比硝普钠低1000倍。压力。 i.c.的增加一氧化氮合酶（NOS）抑制剂N-硝基-L-精氨酸甲酯（L-NAME）减弱了响应NaNO2的压力。 i.c.的增加黄嘌呤氧化还原酶抑制剂别嘌呤醇不会改变对NaNO2的反应压力。响应于i.c.的全身动脉压降低NaNO2的注射被别嘌呤醇减弱，或不变或被L-NAME增加。这些数据表明NaNO 2在大鼠的海绵体和系统性血管床中被转化为血管活性NO。目前的数据表明，NaNO2向血管活性NO的转化是由海绵体中的NOS和大鼠全身性血管床中的黄嘌呤氧化还原酶介导的。这些数据表明，NaNO 2可以作为NO供体，增加大鼠的勃起活性。

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