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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of low-dose ketanserin on atherosclerosis in rats and rabbits.
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Effects of low-dose ketanserin on atherosclerosis in rats and rabbits.

机译：小剂量酮色林对大鼠和兔子动脉粥样硬化的影响。

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摘要

The present study was designed to test the hypothesis that a small dose of ketanserin, which enhances baroreflex activity, prevents the early lesions of atherosclerosis. In experiment 1, baroreflex sensitivity (BRS) was measured in 31 spontaneously hypertensive rats (SHRs) in a conscious state using a computerized blood pressure monitoring system. Four weeks later, the rats were administered vitamin D3 and fed a high-cholesterol diet for 8 weeks to induce atherosclerosis. Then their hearts and aortae were removed for pathological examination. A negative correlation was found between BRS and the scores of coronary (r = -0.460, P < 0.01) and aortic atherosclerosis (r = -0.448, P < 0.05) in SHR. In experiment 2, SHRs were divided into 3 groups (n = 10 in each group) and received a dose of ketanserin of 0.3, 1.0, and 3.0 mg/kg (i.g.), respectively. At the smallest dose (0.3 mg/kg), ketanserin did not lower blood pressure but enhanced BRS. In experiment 3, SHRs were administered vitamin D3, fed a high-cholesterol diet, and simultaneously treated with low-dose ketanserin. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (coronary score: 0.90 +/- 0.14 vs. 1.76 +/- 0.27, P < 0.05; aortic scores: 1.00 +/- 0.39 vs. 2.18 +/- 0.41, P < 0.05). In experiment 4, male New Zealand White rabbits were fed a high-cholesterol diet and treated with low-dose ketanserin at the same time. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (aortic scores: 0.26 +/- 0.20 vs. 0.60 +/- 0.31, P < 0.05). In conclusion, the present study demonstrated, for the first time, that low-dose ketanserin prevented the development of atherosclerosis independent of its blood pressure lowering action in SHRs and New Zealand White rabbits at least in part via enhancement of arterial baroreflex function.
机译：本研究旨在检验以下假设：小剂量的酮色林可增强压力反射活动，可预防动脉粥样硬化的早期病变。在实验1中，使用计算机血压监测系统在意识状态下的31只自发性高血压大鼠（SHR）中测量了压力反射敏感性（BRS）。四周后，给大鼠服用维生素D3，并喂食高胆固醇饮食8周，以诱发动脉粥样硬化。然后取出他们的心脏和主动脉进行病理检查。在SHR中，BRS与冠状动脉评分（r = -0.460，P <0.01）和主动脉粥样硬化评分（r = -0.448，P <0.05）之间呈负相关。在实验2中，SHR分为3组（每组n = 10），并分别接受0.3、1.0和3.0 mg / kg（i.g。）的酮色林剂量。在最小剂量（0.3 mg / kg）下，酮色林没有降低血压，但增强了BRS。在实验3中，给SHRs服用维生素D3，喂养高胆固醇饮食，并同时用小剂量的酮色林治疗。治疗组的动脉粥样硬化评分明显低于对照组（冠状评分：0.90 +/- 0.14 vs. 1.76 +/- 0.27，P <0.05;主动脉评分：1.00 +/- 0.39 vs. 2.18 + / -0.41，P <0.05）。在实验4中，给雄性新西兰白兔饲喂高胆固醇饮食，并同时用小剂量的酮色林治疗。治疗组的动脉粥样硬化评分显着低于对照组（主动脉评分：0.26 +/- 0.20对0.60 +/- 0.31，P <0.05）。总之，本研究首次证明，低剂量的酮色林可以独立于SHR和新西兰白兔的血压降低作用而阻止动脉粥样硬化的发展，至少部分是通过增强动脉压力反射功能来实现的。

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