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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Perinatal oxygen in the developing lung
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Perinatal oxygen in the developing lung

机译：发育中的肺中的围产期氧气

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摘要

Lung diseases, such as bronchopulmonary dysplasia (BPD), wheezing, and asthma, remain significant causes of morbidity and mortality in the pediatric population, particularly in the setting of premature birth. Pulmonary outcomes in these infants are highly influenced by perinatal exposures including prenatal inflammation, postnatal intensive care unit interventions, and environmental agents. Here, there is strong evidence that perinatal supplemental oxygen administration has significant effects on pulmonary development and health. This is of particular importance in the preterm lung, where premature exposure to room air represents a hyperoxic insult that may cause harm to a lung primed to develop in a hypoxic environment. Preterm infants are also subject to increased episodes of hypoxia, which may also result in pulmonary damage and disease. Here, we summarize the current understanding of the effects of oxygen on the developing lung and how low vs. high oxygen may predispose to pulmonary disease that may extend even into adulthood. Better understanding of the underlying mechanisms will help lead to improved care and outcomes in this vulnerable population.
机译：肺部疾病，例如支气管肺发育不良（BPD），喘息和哮喘，仍然是儿童人群发病和死亡的重要原因，尤其是在早产的情况下。这些婴儿的肺结局在很大程度上受到围产期暴露的影响，包括产前炎症，产后重症监护病房干预措施和环境因素。在这里，有充分的证据表明围产期补充氧气对肺部发育和健康具有重大影响。这对于早产肺尤为重要，在早产肺中，过早暴露于室内空气会导致高氧损伤，可能会对在缺氧环境中发育的肺造成伤害。早产儿还容易发生缺氧，这也可能导致肺部损伤和疾病。在这里，我们总结了目前对氧气对发育中的肺的影响以及低氧气与高氧气可能会导致甚至可能延续到成年期的肺部疾病的易感性的认识。对基本机制的更好理解将有助于改善这一弱势群体的护理水平和结果。

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