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首页> 外文期刊>Frontiers in neuroendocrinology >GABA(A) receptor-acting neurosteroids: A role in the development and regulation of the stress response
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GABA(A) receptor-acting neurosteroids: A role in the development and regulation of the stress response

机译：GABA（A）受体作用神经甾体：在应激反应的发展和调节中的作用

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Regulation of hypothalamic-pituitary-adrenocortical (HPA) axis activity by stress is a fundamental survival mechanism and HPA-dysfunction is implicated in psychiatric disorders. Adverse early life experiences, e.g. poor maternal care, negatively influence brain development and programs an abnormal stress response by encoding long-lasting molecular changes, which may extend to the next generation. How HPA-dysfunction leads to the development of affective disorders is complex, but may involve GABA(A) receptors (GABA(A)Rs), as they curtail stress-induced HPA axis activation. Of particular interest are endogenous neurosteroids that potently modulate the function of GABA(A)Rs and exhibit stress-protective properties. Importantly, neurosteroid levels rise rapidly during acute stress, are perturbed in chronic stress and are implicated in the behavioural changes associated with early-life adversity. We will appraise how GABA(A)R-active neurosteroids may impact on HPA axis development and the orchestration of the stress-evoked response. The significance of these actions will be discussed in the context of stress-associated mood disorders. (C) 2014 The Authors. Published by Elsevier Inc.
机译：应激调节下丘脑-垂体-肾上腺皮质（HPA）轴活动是一种基本的生存机制，HPA功能障碍与精神疾病有关。不良的早期生活经历，例如产妇护理不佳，会通过编码持久的分子变化来对大脑发育产生负面影响，并制定异常的应激反应，这种变化可能会延续到下一代。 HPA功能障碍如何导致情感障碍的发展是复杂的，但可能会涉及GABA（A）受体（GABA（A）Rs），因为它们会减少应激诱导的HPA轴激活。特别引起关注的是内源性神经固醇，其有效调节GABA（A）Rs的功能并表现出应激保护特性。重要的是，神经类固醇水平在急性应激期间会迅速升高，在慢性应激中会受到干扰，并与早年逆境有关的行为改变有关。我们将评估GABA（A）R活性神经甾体可能如何影响HPA轴的发育和应激诱发反应的编排。这些动作的重要性将在与压力有关的情绪障碍的背景下进行讨论。 （C）2014作者。由Elsevier Inc.发布

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