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首页> 外文期刊>Frontiers in neuroendocrinology >The neurocircuitry involved in oxytocin modulation of methamphetamine addiction
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The neurocircuitry involved in oxytocin modulation of methamphetamine addiction

机译：催产素调节甲基苯丙胺成瘾的神经回路

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摘要

The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the psychostimulant methamphetamine, has been examined with increased ferocity in recent years. This is largely driven by the potential application of oxytocin as a pharmacotherapy. However, the neural mechanisms by which oxytocin modulates methamphetamine abuse are not well understood. Recent research identified an important role for the accumbens core and subthalamic nucleus in this process, which likely involves an interaction with dopamine, glutamate, GABA, and vasopressin. In addition to providing an overview of methamphetamine, the endogenous oxytocin system, and the effects of exogenous oxytocin on drug abuse, we propose a neural circuit through which exogenous oxytocin modulates methamphetamine abuse, focusing on its interaction with neurochemicals within the accumbens core and subthalamic nucleus. A growing understanding of exogenous oxytocin effects at a neurochemical and neurobiological level will assist in its evaluation as a pharmacotherapy for drug addiction. Crown Copyright (C) 2016 Published by Elsevier Inc. All rights reserved.
机译：近年来，已经研究了催产素在减轻包括精神兴奋药甲基苯丙胺在内的合法药物和非法药物滥用中的作用，其凶猛性得到了提高。这在很大程度上是由催产素作为药物疗法的潜在应用所驱动。然而，催产素调节甲基苯丙胺滥用的神经机制尚不清楚。最近的研究确定了伏隔核和丘脑底核在此过程中的重要作用，这可能涉及与多巴胺，谷氨酸，GABA和加压素的相互作用。除了概述甲基苯丙胺，内源性催产素系统以及外源性催产素对药物滥用的影响外，我们还提出了一种神经回路，外源性催产素通过该神经回路调节甲基苯丙胺滥用，重点在于其与伏隔核和丘脑底核内的神经化学物质的相互作用。 。在神经化学和神经生物学水平上对外源催产素作用的日益了解将有助于其作为药物成瘾的药物疗法进行评估。 Crown版权所有（C）2016，由Elsevier Inc.保留。保留所有权利。

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