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首页> 外文期刊>Frontiers in neuroendocrinology >Alterations in the corticotropin-releasing hormone (CRH) neurocircuitry: Insights into post stroke functional impairments
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Alterations in the corticotropin-releasing hormone (CRH) neurocircuitry: Insights into post stroke functional impairments

机译：促肾上腺皮质激素释放激素（CRH）神经回路的改变：中风后功能障碍的见解。

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Although it is well accepted that changes in the regulation of the hypothalamic-pituitary adrenal (HPA) axis may increase susceptibility to affective disorders in the general population, this link has been less examined in stroke patients. Yet, the bidirectional association between depression and cardiovascular disease is strong, and stress increases vulnerability to stroke. Corticotropin-releasing hormone (CRH) is the central stress hormone of the HPA axis pathway and acts by binding to CRH receptors (CRHR) 1 and 2, which are located in several stress-related brain regions. Evidence from clinical and animal studies suggests a role for CRH in the neurobiological basis of depression and ischemic brain injury. Given its importance in the regulation of the neuroendocrine, autonomic, and behavioral correlates of adaptation and maladaptation to stress, CRH is likely associated in the pathophysiology of post stroke emotional impairments. The goals of this review article are to examine the clinical and experimental data describing (1) that CRH regulates the molecular signaling brain circuit underlying anxiety- and depression-like behaviors, (2) the influence of CRH and other stress markers in the pathophysiology of post stroke emotional and cognitive impairments, and (3) context and site specific interactions of CRH and BDNF as a basis for the development of novel therapeutic targets. This review addresses how the production and release of the neuropeptide CRH within the various regions of the mesocorticolimbic system influences emotional and cognitive behaviors with a look into its role in psychiatric disorders post stroke. (C) 2016 Elsevier Inc. All rights reserved.
机译：尽管人们普遍认为下丘脑-垂体-肾上腺（HPA）轴的调节变化可能会增加普通人群对情感障碍的易感性，但在卒中患者中对此联系的研究较少。然而，抑郁症和心血管疾病之间的双向关联很强，并且压力增加了中风的易感性。促肾上腺皮质激素释放激素（CRH）是HPA轴途径的中央应激激素，通过与位于几个与压力相关的大脑区域的CRH受体（CRHR）1和2结合而起作用。来自临床和动物研究的证据表明，CRH在抑郁症和缺血性脑损伤的神经生物学基础中起作用。鉴于其在调节神经适应性和适应不良的神经内分泌，自主性和行为相关性方面的重要性，CRH可能与中风后情绪障碍的病理生理有关。这篇综述文章的目的是检查描述以下方面的临床和实验数据：（1）CRH调节焦虑和抑郁样行为背后的分子信号传导脑回路;（2）CRH和其他应激标志物在人的病理生理中的影响中风后的情绪和认知障碍，以及（3）CRH和BDNF的背景和特定部位相互作用，作为开发新型治疗靶标的基础。这篇综述通过研究其在中风后精神病中的作用，探讨了中皮层皮质系统各区域内神经肽CRH的产生和释放如何影响情绪和认知行为。 （C）2016 Elsevier Inc.保留所有权利。

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