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首页> 外文期刊>Frontiers in neuroendocrinology >Endocrine and social regulation of adult neurogenesis in songbirds
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Endocrine and social regulation of adult neurogenesis in songbirds

机译：鸣禽成年神经发生的内分泌和社会调控

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The identification of pronounced seasonal changes in the volume of avian song control nuclei stimulated the discovery of adult neurogenesis in songbirds as well as renewed studies in mammals including humans. Neurogenesis in songbirds is modulated by testosterone and other factors such as photoperiod, singing activity and social environment. Adult neurogenesis has been widely studied by labeling, with tridated thymidine or its analog BrdU, cells duplicating their DNA in anticipation of their last mitotic division and following their fate as new neurons. New methods based on endogenous markers of cell cycling or of various stages of neuronal life have allowed for additional progress. In particular immunocytochemical visualization of the microtubule-associated protein doublecortin has provided an integrated view of neuronal replacement in the song control nucleus HVC. Multiple questions remain however concerning the specific steps in the neuronal life cycle that are modulated by various factors and the underlying cellular mechanisms. (C) 2016 Published by Elsevier Inc.
机译：识别禽歌控制核数量的明显季节性变化，不仅刺激了鸣禽中成年神经发生的发现，而且刺激了包括人类在内的哺乳动物的新研究。鸣禽的神经发生受睾丸激素和其他因素（如光周期，唱歌活动和社交环境）的调节。通过用经过修饰的胸苷或其类似物BrdU标记可复制其DNA的细胞以预期其最后的有丝分裂，并追踪其作为新神经元的命运，已广泛研究了成年神经发生。基于细胞周期或神经元生命各个阶段的内源性标志物的新方法已经取得了新进展。特别地，微管相关蛋白doublecortin的免疫细胞化学可视化提供了歌曲控制核HVC中神经元置换的完整视图。然而，关于神经元生命周期中由各种因素和潜在的细胞机制调节的特定步骤仍然存在多个问题。 （C）2016由Elsevier Inc.发布

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