...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in neuroendocrinology >Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors
【24h】

Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors

机译：炎症，性类固醇和阿尔茨海默氏病危险因素之间的相互作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alzheimer's disease (AD) is an age-related neurodegenerative disorder for which there are no effective strategies to prevent or slow its progression. Because AD is multifactorial, recent research has focused on understanding interactions among the numerous risk factors and mechanisms underlying the disease. One mechanism through which several risk factors may be acting is inflammation. AD is characterized by chronic inflammation that is observed before clinical onset of dementia. Several genetic and environmental risk factors for AD increase inflammation, including apolipoprotein E4, obesity, and air pollution. Additionally, sex steroid hormones appear to contribute to AD risk, with age-related losses of estrogens in women and androgens in men associated with increased risk. Importantly, sex steroid hormones have anti-inflammatory actions and can interact with several other AD risk factors. This review examines the individual and interactive roles of inflammation and sex steroid hormones in AD, as well as their relationships with the AD risk factors apolipoprotein E4, obesity, and air pollution. (C) 2016 Elsevier Inc. All rights reserved.
机译：阿尔茨海默氏病（AD）是一种与年龄有关的神经退行性疾病，目前尚无有效的策略来预防或减缓其进展。由于AD是多因素的，因此最近的研究集中在理解疾病的众多风险因素和机制之间的相互作用。几种危险因素可能起作用的一种机制是炎症。 AD的特征在于在痴呆的临床发作之前观察到的慢性炎症。 AD的几种遗传和环境危险因素会加剧炎症，包括载脂蛋白E4，肥胖和空气污染。此外，性类固醇激素似乎会引起AD风险，与年龄相关的女性雌激素和男性雄激素的损失与风险增加相关。重要的是，性类固醇激素具有抗炎作用，并且可以与其他几种AD危险因素相互作用。这篇综述检查了炎症和性甾体激素在AD中的个体和相互作用作用，以及它们与AD危险因素载脂蛋白E4，肥胖症和空气污染之间的关系。 （C）2016 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号