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首页> 外文期刊>Frontiers in neuroendocrinology >Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis
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Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis

机译:昼夜节律和超昼夜节律性糖皮质激素的节律性:糖皮质激素对神经干细胞和成年海马神经发生的影响

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摘要

Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learning and memory. However, the mechanisms by which stress, and particularly glucocorticoids, inhibit neural stem/progenitor cell proliferation remain unclear and under debate.
机译:社会心理压力,以及在对压力特别是糖皮质激素的压力的神经内分泌反应中,是成人海马中神经干/祖细胞增殖的特征良好的抑制剂,导致该大脑区域与学习相关的新神经元的产生显着减少。和记忆。然而,压力,特别是糖皮质激素,抑制神经干/祖细胞增殖的机制尚不清楚,并且仍在争论中。

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