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The effects of hormones and physical exercise on hippocampal structural plasticity

机译:激素和体育锻炼对海马结构可塑性的影响

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摘要

The hippocampus plays an integral role in certain aspects of cognition. Hippocampal structural plasticity and in particular adult hippocampal neurogenesis can be influenced by several intrinsic and extrinsic factors. Here we review how hormones (i.e., intrinsic modulators) and physical exercise (i.e., an extrinsic modulator) can differentially modulate hippocampal plasticity in general and adult hippocampal neurogenesis in particular. Specifically, we provide an overview of the effects of sex hormones, stress hormones, and metabolic hormones on hippocampal structural plasticity and adult hippocampal neurogenesis. In addition, we also discuss how physical exercise modulates these forms of hippocampal plasticity, giving particular emphasis on how this modulation can be affected by variables such as exercise regime, duration, and intensity. Understanding the neurobiological mechanisms underlying the modulation of hippocampal structural plasticity by intrinsic and extrinsic factors will impact the design of new therapeutic approaches aimed at restoring hippocampal plasticity following brain injury or neurodegeneration. (C) 2016 Elsevier Inc. All rights reserved.
机译:海马在认知的某些方面起着不可或缺的作用。海马的结构可塑性,尤其是成年海马的神经发生,可能受到多种内在和外在因素的影响。在这里,我们回顾了激素(即内在调节剂)和体育锻炼(即外在调节剂)如何在一般和特别是成年海马神经发生中差异地调节海马可塑性。具体而言,我们概述了性激素,应激激素和代谢激素对海马结构可塑性和成年海马神经发生的影响。此外,我们还讨论了体育锻炼如何调节这些形式的海马可塑性,特别强调了这种调节如何受到运动方式,持续时间和强度等变量的影响。了解内在和外在因素调节海马结构可塑性的神经生物学机制将影响旨在恢复脑损伤或神经变性后海马可塑性的新治疗方法的设计。 (C)2016 Elsevier Inc.保留所有权利。

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