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Of patterns and pathways: microarray technologies for the analysis of filamentous fungi

机译:模式和途径:用于分析丝状真菌的微阵列技术

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During recent years, microarrays have been firmly established as valuable tools for the discovery of novel biological phenomena. Especially in combination with whole genome sequences, microarray data can help unravel the dynamics of the expressed genome. For filamentous fungi, microarray studies have already been performed with more than 20 different species; these investigations have explored a variety of different aspects of fungal biology. In this review, I will give an overview of some of the keyquestions that have been addressed using microarray hybridizations with filamentous fungi, with particular focus on the analysis of co-regulated pathways and physically clustered genes, as well as on the use of microarray data to determine a molecular phenotype. Additionally, a number of useful, freely available software tools for the analysis of fungal microarray data will be discussed.
机译:近年来,微阵列已被牢固地确立为发现新型生物现象的有价值的工具。尤其是与整个基因组序列结合使用时,微阵列数据可以帮助阐明表达的基因组的动力学。对于丝状真菌,已经对20多种不同的物种进行了微阵列研究。这些研究探索了真菌生物学的各个不同方面。在这篇综述中,我将概述使用微阵列杂交技术与丝状真菌解决的一些关键问题,特别侧重于共同调控途径和物理聚类基因的分析,以及微阵列数据的使用确定分子表型。另外,将讨论用于分析真菌微阵列数据的许多有用的,可免费获得的软件工具。

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