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Fungal endophytes and bioprospecting

机译:真菌内生菌和生物勘探

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摘要

Horizontally transmitted fungal endophytes are an ecological group of fungi, mostly belonging to the Ascomycota, that reside in the aerial tissues and roots of plants without inducing any visual symptoms of their presence. These fungi appear to have acapacity to produce an array of secondary metabolites exhibiting a variety of biological activity. Although the ability of fungi to produce unique bioactive metabolites is well known, endophytes have not been exploited, perhaps because we are only beginning to understand their distribution and biology. This review emphasizes the need to routinely include endo-phytic fungi in the screening of organisms for bioactive metabolites and novel drugs; it also underscores the need to use information obtained concerning fungal secondary metabolite production from other groups of fungi for a targeted screening approach.
机译:水平传播的真菌内生菌是生态学上的一种真菌,主要属​​于子囊菌,它们位于植物的气生组织和根中,而不会引起其存在的任何视觉症状。这些真菌似乎具有产生一系列具有多种生物活性的次级代谢产物的能力。尽管真菌产生独特的生物活性代谢物的能力是众所周知的,但尚未开发出内生菌,这也许是因为我们才刚刚开始了解它们的分布和生物学特性。这篇综述强调了在生物体中筛选生物活性代谢产物和新药时必须常规包括内生真菌的问题。它还强调需要使用从其他真菌类群获得的有关真菌次生代谢产物的信息进行有针对性的筛选。

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