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首页> 外文期刊>Fungal Biology Reviews >Galleria mellonella larvae as models for studying fungal virulence.
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Galleria mellonella larvae as models for studying fungal virulence.

机译：黑麦草幼虫作为研究真菌毒力的模型。

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摘要

As a result of the strong structural and functional similarities between the innate immune system of mammals and the insect immune response, insects have been exploited for evaluating the virulence of fungal pathogens of humans and for assessing the efficacy of anti-fungal agents. There is a strong correlation between the results obtained using insects and mammals and insects have the added advantage of being cheap to purchase, give results in 24-48 h and are without the ethical and legal restrictions associated with the use of mammals. Larvae of Galleria mellonella are excellent in vivo models and have been used with a variety of fungi and anti-fungal agents. Factors affecting the use of G. mellonella larvae are described and examples of where these larvae have been utilized are discussed.Digital Object Identifier http://dx.doi.org/10.1016/j.fbr.2010.04.001
机译：由于哺乳动物的先天免疫系统与昆虫免疫应答之间在结构和功能上有很强的相似性，因此已经利用昆虫来评估人类真菌病原体的毒力并评估抗真菌剂的功效。使用昆虫和哺乳动物获得的结果之间有很强的相关性，而昆虫的另一个优势是价格便宜，可以在24-48小时内获得结果，并且没有与使用哺乳动物相关的道德和法律限制。 梅勒氏菌的幼虫是出色的体内模型，已与多种真菌和抗真菌剂一起使用。影响 G使用的因素。描述了蜜瓜幼虫，并讨论了利用这些幼虫的例子。数字对象标识符http://dx.doi.org/10.1016/j.fbr.2010.04.001

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