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Population genomics and speciation in yeasts.

机译:酵母菌的种群基因组学和物种形成。

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The advent of efficient whole genome sequencing and the large molecular and genetic toolbox available for studies in Saccharomyces cerevisiae and related species have allowed unprecedented analysis of big issues such as: what causes reproductive isolation and eventual speciation? The species complex encompassing S. cerevisiae and relatives consists of six species and several naturally occurring hybrids, which have nearly collinear genomes. They fit the biological species definition of within species fertility and between species sterility. There are examples of chromosome rearrangements and of genetic incompatibilities between species of the complex, which contribute to reproductive isolation but these are not universally present. In addition, simple sequence divergence has been shown to cause reproductive isolation via the action of the mismatch repair system. Although all three of these mechanisms contribute to extant reproductive isolation, which if any, drive the speciation process is still an open question. Population genomic surveys of whole genome sequences reveal introgressions and horizontal gene transfers between species, indicating that the species barriers are not complete. This gene flow between species, although infrequent, brings into question the nature of yeast species
机译:有效的全基因组测序的出现以及可用于酿酒酵母和相关物种研究的大型分子和遗传工具箱的出现,使人们对诸如以下的重大问题进行了空前的分析:什么原因导致生殖分离和最终形成物种?包含 S的物种复合体。酿酒酵母及其亲缘种由六个物种和几种自然杂种组成,它们具有几乎共线的基因组。它们符合物种繁殖力内和物种不育之间的生物学物种定义。存在染色体重排和复合物物种之间遗传不相容的例子,这些例子有助于生殖分离,但并不普遍存在。此外,简单的序列差异已显示出通过错配修复系统的作用导致生殖隔离。尽管所有这三种机制都有助于现存的生殖隔离,但如果有的话,这会驱动物种形成过程仍然是一个悬而未决的问题。整个基因组序列的人口基因组调查显示种间渗入和种间水平基因转移,表明种间屏障不完整。物种之间的这种基因流动虽然很少,但令人质疑酵母物种的性质

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