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Fungal pathogenesis: past, present and future.

机译:真菌发病机理:过去,现在和将来。

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Over the last 20 years a record number of fungal and fungal-like diseases have jeopardized wild species the world over, causing several of the most severe population declines and extinctions ever witnessed (Fisher et al. 2012). Such events include the devastating impact of Batrachochytrium dendrobatidis on amphibian populations and the extinction of bat populations as a result of Geomyces destructans infection. This commentary focusses on two human-infecting fungal pathogens causing much scientific interest, that is, Cryptococcus gattii and Trichophyton rubrum. It summarises recent research findings into their pathogenic evolution and adaptive strategies and highlights key gaps in our knowledge. Finally, the prose attempts to fuse such data with the work of Casadevall, exploiting his theories to predict the future of fungal pathogenesis, that is, where pathogenesis refers to the mechanism that results in disease (Casadevall 2012).
机译:在过去的20年中,创纪录数量的真菌和类真菌病危害了世界各地的野生物种,造成了有史以来最严重的种群减少和灭绝事件(Fisher等人,2012)。这些事件包括毁灭性巴氏梭菌对两栖动物的毁灭性影响以及由于毁灭性Geomyces感染而导致蝙蝠种群的灭绝。这篇评论的重点是引起人类广泛关注的两种感染人类的​​真菌病原体,即加氏隐球菌和红毛癣菌。它总结了有关其致病性进化和适应策略的最新研究发现,并突出了我们知识的主要空白。最后,散文试图将这些数据与Casadevall的工作融合在一起,利用他的理论来预测真菌性发病机理的未来,也就是说,发病机理是指导致疾病的机制(Casadevall 2012)。

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