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首页> 外文期刊>Canadian Journal of Animal Science >Effects of an early lipopolysaccharide challenge on growth and small intestinal structure and function of broiler chickens.
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Effects of an early lipopolysaccharide challenge on growth and small intestinal structure and function of broiler chickens.

机译：早期脂多糖攻击对肉鸡生长，小肠结构和功能的影响。

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Two experiments were conducted to determine the effect of early exposure to lipopolysaccharide (LPS) on small intestinal structure and function of broiler chickens. Seven-day-old birds were randomly allotted to two equal treatments: an LPS-injected treatment in which the birds were injected intraperitoneally with LPS 500 micro g kg-1 body weight (dissolved in 1 mL saline) on 8, 10, 12, 15, 17, and 19 d of age, i.e., on days 1, 3, and 5 d for 2 continuous weeks, and a control treatment (CTRL) in which the birds were similarly injected with 1 mL saline as a placebo. In exp. 1, food intake and weight gain were monitored over the 2 wk, the weight of the small bowel was determined at 14 and 21 d of age and duodenal and jejunal villus height and crypt depth, D-xylose uptake were also measured at 21 d. In exp. 2, additional measurements of the intestinal peristalsis ratio and the BrdU-labeling index and duodenal sodium-glucose co-transporter-1 (SGLT1) mRNA level were made at 21 d of age. The results showed that LPS challenge decreased feed intake, daily gain, duodenal and jejunal villus height and crypt depth, plasma D-xylose concentration and intestinal BrdUrd-labeling index, respectively (P<0.05) as well as small bowel weight at 14 and 21 d of age (P<0.05). Conversely, LPS injection increased SGLT1 mRNA level in the small intestine (P<0.05) and the small intestinal relative weight at 14 (P<0.05) and 21 d of age (P=0.063). Following LPS injection there were non-significant changes in feed conversion ratio and intestinal peristalsis ratio (P
机译：进行了两项实验，以确定早期暴露于脂多糖（LPS）对肉鸡小肠结构和功能的影响。将7天大的家禽随机分配给两个相同的处理：注射LPS的处理，其中给家禽腹膜内注射500 micro g kg -1 体重的LPS（溶于1 mL盐水中）在第8天，第10天，第12天，第15天，第17天和第19天，即连续第2天的第1天，第3天和第5天，以及对照处理（CTRL）中，类似地向家禽注射1 mL盐作为安慰剂。在实验中如图1所示，在2周内监测食物的摄入量和体重增加，在14和21 d时测定小肠的重量，十二指肠和空肠绒毛的高度和隐窝深度也要在21 d时测量。在实验中如图2所示，在21岁时进行了肠蠕动率和BrdU标记指数以及十二指肠钠-葡萄糖共转运蛋白1（SGLT1）mRNA水平的其他测量。结果表明，LPS刺激分别降低了采食量，日增重，十二指肠和空肠绒毛高度和隐窝深度，血浆D-木糖浓度和肠道BrdUrd标记指数（ P <0.05）以及在14和21 d时肠重量较小（ P <0.05）。相反，LPS注射会在14岁（ P <0.05）和21天龄时增加小肠的SGLT1 mRNA水平（ P <0.05）和小肠相对重量（ P <0.05） P = 0.063）。注射LPS后，饲料转化率和肠蠕动率没有显着变化（ P

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