...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effect of U and 137Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat.
【24h】

Effect of U and 137Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat.

机译：铀和137Cs慢性污染对大鼠中枢神经系统多巴胺和5-羟色胺代谢的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Following the Chernobyl accident, the most significant problem for the population of the former Soviet Union for the next 50-70 years will be chronic internal contamination by radionuclides. One of the few experiments carried out in this field reported that neurotransmitter metabolism in the central nervous system of the rat was disturbed after feeding with oats contaminated by 137Cs for 1 month. The present study assessed the effect of chronic contamination by depleted U or 137Cs on the metabolism of two neurotransmitters in cerebral areas of rats. Dopamine and serotonin were chosen because their metabolism has been shown to be disturbed after external irradiation, even at moderate doses. Dopamine, serotonin, and some of their catabolites were measured by high-pressure liquid chromatography coupled with an electrochemical detector in five cerebral structures of rats contaminated over a 1-month period by drinking water (40 mg U.L–1 or 6500 Bq 137Cs.L–1). In the striatum, hippocampus, cerebral cortex, thalamus, and cerebellum, the dopamine, serotonin, and catabolite levels were not significantly different between the control rats and rats contaminated by U or 137Cs. These results are not in accordance with those previously described.
机译：切尔诺贝利事故之后，未来50-70年间前苏联人民面临的最重大问题将是放射性核素对内部的长期污染。该领域进行的少数实验之一报告说，喂食受137Cs污染的燕麦1个月后，大鼠中枢神经系统的神经递质代谢受到干扰。本研究评估了贫铀或137Cs慢性污染对大鼠脑区域两种神经递质代谢的影响。之所以选择多巴胺和5-羟色胺，是因为即使在中等剂量的照射下，它们的代谢也会受到干扰。多巴胺，5-羟色胺及其某些分解代谢物是通过高压液相色谱仪结合电化学检测器在1个月内被饮用水（40 mg UL-1或6500 Bq 137Cs.L）污染的大鼠的五个大脑结构中测量的。 –1）。在纹状体，海马，大脑皮层，丘脑和小脑中，对照大鼠与被U或137Cs污染的大鼠之间的多巴胺，5-羟色胺和分解代谢产物水平无显着差异。这些结果与先前描述的结果不一致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号