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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effect of estrogen replacement treatment on ischemic preconditioning in isolated rat hearts.
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Effect of estrogen replacement treatment on ischemic preconditioning in isolated rat hearts.

机译：雌激素替代治疗对离体大鼠心脏缺血预处理的影响。

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摘要

In the present study, we tested the effects of long-term estrogen replacement treatment on myocardial ischemia-reperfusion injury and on the cardioprotection of ischemic preconditioning in isolated hearts from ovariectomized rats. Ovariectomized rats were treated with 17β-estradiol (30 micro g/kg/d, s.c.) for 12 weeks. Isolated rat hearts were perfused in the Langendorff mode. Heart rate, coronary flow, left ventricular pressure and its first derivative (+/-LVdp/dtmax) were recorded. Fifteen-min global ischemia and 30-min reperfusion caused a significant decrease of cardiac mechanical function, which were not affected by ovariectomy or estrogen replacement treatment. The isolated hearts in all groups could be preconditioned, and the cardioprotection afforded by preconditioning in the sham-operated rats was greater compared with ovariectomized rats with or without estrogen treatment. These results suggest that long-term estrogen replacement treatment exerts no effect on the inhibition of mechanicalfunction after ischemia-reperfusion, and this study also suggests that estrogen does not affect ischemic preconditioning in isolated hearts of ovariectomized rats.
机译：在本研究中，我们测试了长期雌激素替代治疗对去卵巢大鼠离体心脏缺血再灌注的心肌保护作用和对缺血预处理的心脏保护作用。去卵巢的大鼠用17β-雌二醇（30 micro g / kg / d，s.c.）治疗12周。以Langendorff模式灌注离体的大鼠心脏。记录心率，冠状动脉血流，左心室压力及其一阶导数（+/- LVdp / dtmax）。全身缺血15分钟和再灌注30分钟导致心脏机械功能显着下降，这不受卵巢切除术或雌激素替代治疗的影响。可以对所有组中的离体心脏进行预处理，与接受或不接受雌激素治疗的去卵巢大鼠相比，假手术大鼠通过预处理提供的心脏保护作用更大。这些结果表明，长期雌激素替代治疗对缺血-再灌注后的机械功能抑制没有作用，并且该研究还表明，雌激素不影响去卵巢大鼠离体心脏的缺血预处理。

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