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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Rapid biphasic arteriolar dilations induced by skeletal muscle contraction are dependent on stimulation characteristics.
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Rapid biphasic arteriolar dilations induced by skeletal muscle contraction are dependent on stimulation characteristics.

机译:骨骼肌收缩引起的快速双相小动脉扩张取决于刺激特征。

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To test the hypothesis that measurable changes in microvasculature dilation occur in response to a single short-duration tetanic contraction, we contracted three to five skeletal muscle fibres of the hamster cremaster muscle microvascular preparation (in situ) and evaluated the response of an arteriole overlapping the active muscle fibres. Arteriolar diameter (baseline diameter = 16.4 +/- 0.9 micro m, maximum diameter = 34.7 +/- 1.2 micro m) was measured before and after a single contraction resulting from a range of stimulus frequencies (4, 10, 20, 30, 40, 60, and 80 Hz) within a 250- or 500-ms train. Four and 10 Hz produced a significant dilation at 2.9 +/- 0.4 and 6.5 +/- 2.8 s, respectively, within a 250-ms train and 3.0 +/- 0.2 and 6.1 +/- 1.3 s, respectively, within a 500-ms train. Biphasic dilations were observed within a 250-ms train at 20 Hz (at 3.9 +/- 0.9 and 22.1 +/- 4.3 s), 30 Hz (at 2.7 +/- 0.3 and 17.5 +/- 2.9 s), and 40 Hz (at 3.8 +/- 0.4 and 23.2 +/- 2.6 s) and within a 500-ms train at20 Hz (at 4.8 +/- 0.4 and 31.9 +/- 3.8 s) and 30 Hz (at 3.4 +/- 0.3 and 27.6 +/- 3.0 s). A single dilation was observed within a 250-ms train at 60 Hz (at 5.1 +/- 0.7 s) and 80 Hz (at 14.2 +/- 3.3 s) and within a 500-ms train at 40 Hz (at 9.9 +/- 3.2 s), 60 Hz (at 7.9 +/- 2.1 s), and 80 Hz (at 13.4 +/- 4.0 s). We have shown that a single contraction ranging from a single twitch (4 Hz, 250 ms) to fused tetanic contractions produces significant arteriolar dilations and that the pattern of dilation is dependent on the stimulus frequency and train duration.
机译:为了检验这一假设,即对单个短时强直性强直性收缩的反应,微血管扩张发生了可测量的变化,我们收缩了仓鼠提睾肌微血管制剂(原位)的三到五根骨骼肌纤维,并评估了与活跃的肌肉纤维。在一系列频率(4、10、20、30、40刺激)引起的单次收缩前后测量小动脉直径(基线直径= 16.4 +/- 0.9微米,最大直径= 34.7 +/- 1.2微米) ,60和80 Hz)在250或500毫秒的序列中。 4和10 Hz在250毫秒序列内分别在2.9 +/- 0.4和6.5 +/- 2.8 s处产生了明显的膨胀,而在500-ms内分别产生了3.0 +/- 0.2和6.1 +/- 1.3 s的显着膨胀。女士列车。在250 Hz的火车中,在20 Hz(3.9 +/- 0.9和22.1 +/- 4.3 s),30 Hz(在2.7 +/- 0.3和17.5 +/- 2.9 s)和40 Hz的情况下,观察到双相膨胀(在3.8 +/- 0.4和23.2 +/- 2.6 s时)以及在500毫秒的频率范围内以20 Hz(在4.8 +/- 0.4和31.9 +/- 3.8 s)和30 Hz(在3.4 +/- 0.3和27.6 +/- 3.0 s)。在60赫兹(5.1 +/- 0.7 s)和80赫兹(14.2 +/- 3.3 s)的250毫秒序列内以及40赫兹(9.9 +/-)的500毫秒序列内观察到单个扩张-3.2 s),60 Hz(在7.9 +/- 2.1 s)和80 Hz(在13.4 +/- 4.0 s)。我们已经表明,从单个抽搐(4 Hz,250 ms)到融合的强直性收缩的单个收缩会产生明显的小动脉扩张,并且扩张的模式取决于刺激频率和训练持续时间。

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