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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Systemic inflammation and mortality in chronic obstructive pulmonary disease.
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Systemic inflammation and mortality in chronic obstructive pulmonary disease.

机译：慢性阻塞性肺疾病的全身炎症和死亡率。

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摘要

Cardiovascular diseases and cancer (especially lung cancer) are leading causes of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). Some have implicated systemic inflammation, which is commonly observed in COPD, as the potential mechanistic bridge between COPD and these disorders. This concept has been supported by animal studies especially in rabbits, which have clearly demonstrated the effect of local lung inflammation on systemic inflammation and on the progression of atherosclerosis and by cross-sectional population-based studies, which have shown a significant relationship between systemic inflammation, as measured by circulating C-reactive protein (CRP) and the risk of cardiovascular diseases in COPD patients. These data have been further extended by a recent study that has elucidated the temporal nature of the relationship between systemic inflammation and the risk of cardiovascular events and cancer in COPD patients. This study showed that baseline CRP levels predicted the incidence of cardiovascular events and cancer-specific mortality over 7 to 8 years of follow-up. CRP levels also predicted all-cause mortality. Collectively, these data indicate that systemic inflammation may play an important role in mediating the extra-pulmonary complications of COPD. Systemic inflammation may contribute substantially to the overall morbidity and mortality of COPD patients.
机译：心血管疾病和癌症（尤其是肺癌）是慢性阻塞性肺疾病（COPD）患者发病和死亡的主要原因。一些涉及系统性炎症，这是COPD和这些疾病之间潜在的机制桥梁，通常在COPD中观察到。这一概念得到了动物研究的支持，尤其是在兔子中，这清楚地证明了局部肺部炎症对全身性炎症和动脉粥样硬化进展的影响，以及基于人群的横断面研究，这些研究表明全身性炎症之间存在显着关系（通过循环C反应蛋白（CRP）和COPD患者的心血管疾病风险来衡量）。最近的一项研究进一步阐明了这些数据，该研究阐明了COPD患者全身性炎症与心血管事件和癌症风险之间关系的时间性。这项研究表明，基线CRP水平可预测7到8年的随访期间心血管事件和癌症特异性死亡率的发生率。 CRP水平还预测了全因死亡率。总的来说，这些数据表明全身性炎症可能在介导COPD的肺外并发症中起重要作用。全身性炎症可能对COPD患者的整体发病率和死亡率有重大贡献。

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