Sequential alterations in Akt, GSK3beta, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.

Previlon M; Pezet M; Dachez C; Mercadier JJ; Rouet Benzineb P

首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Sequential alterations in Akt, GSK3beta, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.

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Sequential alterations in Akt, GSK3beta, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.

机译：胸主动脉缩窄后小鼠左心室中Akt，GSK3beta和钙调神经磷酸信号的顺序变化。

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Left ventricular hypertrophy (LVH) is an adaptive response to chronic biomechanical stress that generally progresses to maladaptive hypertrophy and heart failure (HF). We studied the activation of protein kinase B (Akt/PKB), glycogen synthase kinase 3 beta (GSK3beta), and calcineurin (Cn) at 3, 7, 15, 30, and 60 days following transverse aortic constriction (TAC) in 4-week-old mice. Following TAC, GSK3beta inactivation at day 3 was associated with Akt activation, whereas at days 15 and 30, it appeared to be controlled by other kinases. Moderate nonsignificant Cn activation occurred at the early stages, and peak activation at day 30, concomitant with GSK3beta inactivation and overt LVH and HF. At the latest stage (day 60), despite further progression of LVH and HF, Cn activation appeared attenuated. Early stages of LVH were associated with Ca2+-handling protein upregulation, whereas major Cn activation, associated with GSK3beta inactivation, appeared to engage maladaptive hypertrophy and progression to HF associated with Ca2+-handling protein downregulation.

机译：左心室肥大（LVH）是对慢性生物力学应激的适应性反应，通常会发展为适应不良性肥大和心力衰竭（HF）。我们研究了在主动脉缩窄（TAC）后第4、3、7、15、30和60天，蛋白激酶B（Akt / PKB），糖原合酶激酶3 beta（GSK3beta）和钙调神经磷酸酶（Cn）的激活作用。周龄小鼠。 TAC后，第3天的GSK3beta失活与Akt激活相关，而在第15天和第30天，它似乎受其他激酶控制。中度Cn激活不显着早期发生，并在第30天达到峰值激活，并伴有GSK3beta失活和明显的LVH和HF。在最新阶段（第60天），尽管LVH和HF进一步发展，但Cn激活似乎减弱。 LVH的早期与Ca2 +处理蛋白上调有关，而主要的Cn活化与GSK3beta失活有关，似乎参与了适应不良的肥大，并发展为与Ca2 +处理蛋白下调有关的HF。

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《Canadian Journal of Physiology and Pharmacology》 |2010年第11期|共9页
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Previlon M; Pezet M; Dachez C; Mercadier JJ; Rouet Benzineb P;
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1. Sequential alterations in Akt, GSK3beta, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction. [J] . Previlon M, Pezet M, Dachez C, Canadian Journal of Physiology and Pharmacology . 2010,第11期

机译：胸主动脉缩窄后小鼠左心室中Akt，GSK3beta和钙调神经磷酸信号的顺序变化。
2. Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study [J] . Tomoya Nakano, Kenji Onoue, Yasuki Nakada, Scientific reports. . 2018,第1期

机译：急性期Takotsubo综合征左心室β-肾上腺素受体信号的变化：一项人类研究。
3. Proteomics Analysis Revealed an Altered Left Ventricle Protein Profile in a Mouse Model of Transverse Aortic Constriction [J] . Guan Dawei, Zhao Yan, Zhang Yuan, Protein and peptide letters . 2016,第2期

机译：蛋白质组学分析揭示了横向主动脉缩窄小鼠模型中左心室蛋白质的变化。
4. Mechanical and energetic characteristics of the left ventricle calculated from left ventricular pressure and aortic flow signals [C] . Schwartz, L., Ben-Haim, . 1990

机译：根据左心室压力和主动脉血流信号计算出的左心室机械和能量特征
5. 3D Reconstruction of Left Ventricle with Mitral and Aortic Valves from Multiple Axis 2D Echocardiography at Standard Cross Sections and Flow Simulations [D] . Patel, Tatsat Rajendra. 2018

机译：多轴2D超声心动图在标准横截面上用二尖瓣和主动脉瓣进行左心室3D重建和血流模拟
6. High Thoracic Epidural Decreases Perioperative Myocardial Ischemia and Improves Left Ventricle Function in Aortic Valve Replacement Alone or in Addition to CABG Surgery Even with Increased Left Ventricle Mass Index [O] . Ahmed S. Elgebaly, Sameh M. Fathy, Yaser Elbarbary, 2020

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Sequential alterations in Akt, GSK3beta, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.

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