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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action.
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Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action.

机译：Longevinex（修饰的白藜芦醇）对心脏保护作用及其作用机制。

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Although resveratrol has been proven to possess diverse health benefits, several recent reports have demonstrated conflicting results on some aspects of its effects, including its anti-aging properties. Considerable debate appears to exist on the dose and bioavailability of resveratrol, leading to the controversies on its effectiveness. To resolve the problem, we designed a study with a resveratrol formulation that contained resveratrol supplemented with 5% quercetin and 5% rice bran phytate (commercially known as Longevinex). These ingredients were micronized to increase the bioavailability. Sprague-Dawley rats were gavaged with either Longevinex or vehicle (5% quercetin plus 5% rice bran phytate), and rats were sacrificed after 1 or 3 months, when isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion. Longevinex-treated hearts, irrespective of the duration of treatments, revealed superior cardiac performance, reduced infarct size, and induction of survival signals as evidenced by increased Bcl2/Bax ratio and enhanced Akt phosphorylation. In contrast, LC3-II and Beclin were enhanced significantly after 3 months of Longevinex treatment, suggesting that autophagy occurred only after feeding Longevinex to rats for a prolonged period of time. Corroborating with the results of autophagy, Sirt1 and Sirt3 increased significantly only after 3 months of Longevinex treatment, suggesting that enhanced expression of Sirts correlated with induction of autophagy. In concert, Longevinex caused phosphorylation and nuclear translocation of FoxO1, FoxO3a, and FoxO4, indicating involvement of FoxOs with autophagy. Since Sirts and FoxOs are reliable markers of longevity, the results appear to suggest that Longevinex induces longevity after prolonged feeding via induction of autophagy, while it converts death signals into survival signals and provides cardioprotection within a relatively shorter period of time.
机译：尽管白藜芦醇已被证明具有多种健康益处，但最近的一些报道表明，在其影响的某些方面，包括其抗衰老特性，结果相互矛盾。关于白藜芦醇的剂量和生物利用度似乎存在相当多的争论，这引起了关于其有效性的争论。为了解决该问题，我们设计了一项白藜芦醇制剂研究，该制剂中含有白藜芦醇，并添加了5％槲皮素和5％米糠植酸盐（商品名为Longevinex）。将这些成分微粉化以提高生物利用度。用Longevinex或溶媒（5％槲皮素加5％米糠肌醇六磷酸）管饲Sprague-Dawley大鼠，在1或3个月后处死大鼠，当离体的工作心脏进行30分钟局部缺血，然后再灌注2 h。经Longevinex治疗的心脏，无论治疗时间长短，均表现出卓越的心脏功能，梗死面积减小以及存活信号的诱导，如Bcl2 / Bax比增加和Akt磷酸化增强所证明。相比之下，经Longevinex治疗3个月后，LC3-II和Beclin显着增强，这表明自噬仅在将Longevinex长期喂给大鼠后才发生。仅在Longevinex治疗3个月后，Sirt1和Sirt3才显着增加自噬的结果，这表明Sirts表达的增强与自噬的诱导有关。一致地，Longevinex引起FoxO1，FoxO3a和FoxO4的磷酸化和核易位，表明FoxO与自噬有关。由于Sirts和FoxOs是长寿的可靠标志，因此该结果似乎表明Longevinex通过自噬诱导延长进食时间后会长寿，而Longevinex将死亡信号转化为生存信号并在相对较短的时间内提供心脏保护作用。

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