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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >In-stent restenosis after revascularization of myocardium with drug-eluting stents is accompanied by elevated level of blood plasma eosinophil cationic protein.
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In-stent restenosis after revascularization of myocardium with drug-eluting stents is accompanied by elevated level of blood plasma eosinophil cationic protein.

机译：用药物洗脱支架对心肌进行血运重建后的支架内再狭窄伴有血浆嗜酸性粒细胞阳离子蛋白水平升高。

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The aim of this study was to assess the involvement of eosinophil cationic protein, a marker of eosinophil activation, in the development of in-stent restenosis after drug-eluting stent implantation. Follow-up angiography at 6 to 12 months was performed in 32 patients who were treated with percutaneous coronary intervention and implantation of sirolimus-eluting stents. Blood plasma levels of eosinophil cationic protein (ECP) and total immunoglobulin E (IgE) were measured by enzyme-linked immunosorbent assay and the level of C-reactive protein (hs-CRP) by high-sensitivity nephelometry. According to angiography data, in-stent restenosis occurred in 13 patients, while 19 patients did not develop it. There were no differences between the hs-CRP and IgE levels in patients with or without restenosis. In contrast, ECP level was higher in patients with restenosis compared with that in patients without restenosis [17.7 ng/mL (11.2-24.0) vs. 9.0 ng/mL (6.4-12.9), p = 0.017]. The incidence of in-stent restenoses was 63% in patients with ECP level higher than or equal to 11 ng/mL, and 19% in patients with an ECP level lower than 11 ng/mL (p = 0.019). These findings suggest that elevated eosinophil activation may play an important role in the pathogenesis of in-stent restenosis after implantation of drug-eluting stents.
机译：本研究的目的是评估嗜酸性粒细胞阳离子蛋白（嗜酸性粒细胞活化的标志物）在药物洗脱支架植入后支架内再狭窄发展中的作用。在32例接受了经皮冠状动脉介入治疗和西罗莫司洗脱支架植入的患者中，进行了6至12个月的随访血管造影。通过酶联免疫吸附测定法测定血浆中的嗜酸性粒细胞阳离子蛋白（ECP）和总免疫球蛋白E（IgE）的血浆水平，并通过高灵敏度比浊法测定C反应蛋白（hs-CRP）的水平。根据血管造影数据，支架内再狭窄发生在13例患者中，而19例则没有发展。在有或没有再狭窄的患者中，hs-CRP和IgE水平没有差异。相反，再狭窄患者的ECP水平高于未再狭窄患者[17.7 ng / mL（11.2-24.0）对9.0 ng / mL（6.4-12.9），p = 0.017]。在ECP水平高于或等于11 ng / mL的患者中，支架内再狭窄的发生率为63％，在ECP水平低于11 ng / mL的患者中为19％（p = 0.019）。这些发现表明，在植入药物洗脱支架后，嗜酸性粒细胞活化升高可能在支架内再狭窄的发病机理中起重要作用。

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