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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Preventative effects of prostaglandin E1 in combination with iodized olive oil on liver fibrosis after transcatheter arterial chemoembolization in a rabbit model of CCl4-induced liver fibrosis
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Preventative effects of prostaglandin E1 in combination with iodized olive oil on liver fibrosis after transcatheter arterial chemoembolization in a rabbit model of CCl4-induced liver fibrosis

机译：前列腺素E1与加碘橄榄油联用对CCl4诱导的肝纤维化兔模型经导管动脉化疗栓塞后肝纤维化的预防作用

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To explore the preventative effects of prostaglandin E1 (PGE1) on a rabbit model of CCl4-induced liver fibrosis after transcatheter arterial chemoembolization (TACE), we generated a rabbit model of CCl4-induced liver fibrosis by treatment with 40% CCl4 in iodized olive oil for 16 weeks. Body mass and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB), albumin: globulin ratio (A:G), total bilirubin (TBIL), and direct bilirubin (DBIL) were measured. After TACE, the levels of hyaluronic acid (HA), procollagen III (PC III), laminin (LN), and collagen IV (IV-C) were measured, and the severity of liver fibrosis as well as the morphology of liver tissues were determined. Body mass in the model group was significantly decreased from 10 to 16 weeks, and the serum levels of ALT, AST, TP, TBIL, and DBIL levels were significantly increased while the model was being generated; the levels of ALB and A: G were significantly decreased. After TACE, serum levels of HA, PC III, and LN in the group injected with 1.0 mL iodized olive oil (Group B) were higher than in the group that were injected with 1.0 mL iodized olive oil +0.2 mL PGE1 (Group C), whereas the serum levels of IV-C were lower. The severity of liver fibrosis was ameliorated in Group C. The combination of PGE1 and iodized olive oil prevented the development of liver fibrosis following TACE.
机译：为了探讨前列腺素E1（PGE1）对经导管动脉化疗栓塞（TACE）后CCl4诱导的肝纤维化的兔模型的预防作用，我们通过用40％CCl4在碘化橄榄油中处理生成了CCl4诱导的肝纤维化的兔模型。持续16周。体重和血清丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST），总蛋白（TP），白蛋白（ALB），白蛋白：球蛋白比（A：G），总胆红素（TBIL）和直接胆红素（DBIL） ）进行了测量。 TACE后，测量透明质酸（HA），前胶原III（PC III），层粘连蛋白（LN）和胶原IV（IV-C）的水平，并测定肝纤维化的严重程度以及肝组织的形态决心。模型组的体重从10周减少到16周，并且在生成模型的过程中血清ALT，AST，TP，TBIL和DBIL的水平显着增加。 ALB和A：G水平明显降低。 TACE后，注射1.0 mL碘化橄榄油的组（B组）的HA，PC III和LN血清水平高于注射1.0 mL碘化橄榄油+0.2 mL PGE1的组（C组） ，而IV-C的血清水平较低。 C组肝纤维化的严重程度得到改善。PGE1和加碘橄榄油的组合可预防TACE后肝纤维化的发展。

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