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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Vitamin D, phosphate, and vasculotoxicity
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Vitamin D, phosphate, and vasculotoxicity

机译：维生素D，磷酸盐和血管毒性

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摘要

Vascular calcification is a complex process that results in the ectopic deposition of calcium-phosphate hydroxyapatite. Medial and intimal vascular calcification is frequently present in patients with diabetes mellitus and chronic kidney disease (CKD), and markedly increases the morbidity and mortality of these patients. Increased serum levels of calcium and phosphate, along with the use of active vitamin D metabolites, are commonly implicated in the evolvement of vascular wall mineralization in CKD patients. Because CKD patients have lower serum levels of vitamin D, they are routinely prescribed vitamin D supplements that exert a dualistic role that is both healthful and harmful in these patients, perhaps protecting bone health, but at the expense of promoting vascular pathology. This review briefly explains how reducing the phosphate burden in CKD patients could minimize vitamin-D-associated vascular wall calcification.
机译：血管钙化是一个复杂的过程，会导致磷酸钙羟基磷灰石的异位沉积。糖尿病和慢性肾脏病（CKD）患者经常存在内侧和内膜血管钙化，明显增加了这些患者的发病率和死亡率。血清钙和磷酸盐水平的升高，以及使用活性维生素D代谢物，通常与CKD患者血管壁矿化的发展有关。由于CKD患者的血清维生素D含量较低，因此按常规开具处方的维生素D补充剂，对这些患者具有健康和有害的双重作用，也许可以保护骨骼健康，但以促进血管病变为代价。这篇综述简要地解释了减少CKD患者的磷酸盐负担如何最大程度地减少与维生素D相关的血管壁钙化。

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