首页> 外文期刊>Canadian journal of anesthesia: Journal canadien d'anesthesie >Bradycardie severe et asystolie lors d'induction au sevoflurane et sufentanil a faible dose : a propos de trois cas: (Low dose sufentanil and severe bradycardia during induction with sevoflurane: a report of three cases).
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Bradycardie severe et asystolie lors d'induction au sevoflurane et sufentanil a faible dose : a propos de trois cas: (Low dose sufentanil and severe bradycardia during induction with sevoflurane: a report of three cases).

机译:严重剂量的心动过缓或七氟醚或舒芬太尼的诱导剂合适的剂量:propos de trois cas :(七氟醚诱导时低剂量的舒芬太尼和严重的心动过缓:三例报告)。

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OBJECTIVES: In a randomized double blind clinical study using low doses of fentanyl or sufentanil during sevoflurane induction, we observed three cases of severe bradycardia, forcing us to discontinue the study. We wish to describe these three cases.Clinical data: Anesthesia was induced in the three patients, using a single breath technique consisting of a mixture of sevoflurane 8% with a nitrous oxide flow of 3 L.min(-1) and an oxygen flow of 3 L.min(-1). After the patients had lost consciousness, low dose sufentanil was administered (0.025 渭g.kg(-1) for the first patient and 0.1 渭g.kg(-1) for the other two patients). Heart rate fell to 38, 40 and 42 beats.min(-1) respectively two minutes after the sufentanil injection in these three patients, and progressed to asystole in the third. All the patients responded to atropine 0.6 mg iv. CONCLUSION: The addition of sufentanil, even at very low doses, during anesthesia induction with sevoflurane using a single breath technique, may be dangerous because ofpossible bradycardia and even asystole.
机译:目的:在一项七氟醚诱导期间使用低剂量芬太尼或舒芬太尼的随机双盲临床研究中,我们观察到三例严重心动过缓,迫使我们中止研究。我们希望描述这三种情况。临床数据:使用单次呼吸技术在三名患者中诱导麻醉,该技术由8%的七氟醚与3 L.min(-1)的一氧化二氮和氧气的混合物组成3 L.min(-1)。患者失去知觉后,给予低剂量舒芬太尼(第一名患者为0.025μg.kg(-1),其他两名患者为0.1μg.kg(-1))。这三例患者在注射舒芬太尼后两分钟,心率分别降至38、40和42 beats.min(-1),并在第三次进展为停搏。所有患者均对阿托品0.6 mg静脉注射有反应。结论:使用单次呼吸技术用七氟醚麻醉诱导过程中,即使以非常低的剂量添加舒芬太尼,也可能由于心动过缓甚至心律失常而引起危险。

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