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首页> 外文期刊>Canadian journal of anesthesia: Journal canadien d'anesthesie >Intramuscular tramadol increases gastric pH during anesthesia: (L'administration intramusculaire du tramadol augmente le pH gastrique pendant l'anesthesie).
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Intramuscular tramadol increases gastric pH during anesthesia: (L'administration intramusculaire du tramadol augmente le pH gastrique pendant l'anesthesie).

机译：肌内曲马多在麻醉过程中会增加胃的pH值：（肌内注射曲马多在麻醉过程中会增加胃的pH值）。

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摘要

PURPOSE: Tramadol, [(1RS, 2RS)-2-dimethylamino) methyl-1-(3-methoxyphenyl)-cyclohexanol hydrochloride], is an analgesic in clinical use. It has been reported that tramadol inhibits muscarinic type 3 receptor function, which primarily mediates smooth muscle contraction and glandular secretion. We investigated the effects of tramadol on the pH of gastric juices during anesthesia to determine whether tramadol inhibits secretion from the gastric glands. METHODS: ASA physical status I or II adult patients (n = 30) presenting for major elective orthopedic surgery of the upper extremities or mastectomy were enrolled. Patients were randomly assigned to receive treatment with tramadol (n = 10), famotidine (n = 10), or saline (n = 10). General anesthesia was then induced using propofol, vecuronium bromide, and fentanyl. After inducing anesthesia, the gastric pH was measured using pH test paper and, then, 100 mg tramadol, 20 mg famotidine, or saline were injected into the deltoid muscle. Three hours after starting the operation, gastric juice was again aspirated and its gastric pH measured. RESULTS: There were no differences in the pH before anesthesia between the three groups. By contrast, gastric pH was increased in the tramadol group by the same amount as it was in the famotidine group three hours after administering the drugs. Gastric pH of the saline, famotidine, and tramadol groups was 2.6 +/- 2.5, 6.3 +/- 2.0, and 6.4 +/- 0.8, respectively. CONCLUSION: These results suggest that tramadol inhibits the secretion of gastric acid.
机译：用途：曲马多[[（1RS，2RS）-2-二甲基氨基）甲基-1-（3-甲氧基苯基）-环己醇盐酸盐]，在临床上是一种止痛药。据报道，曲马多抑制毒蕈碱型3型受体功能，主要介导平滑肌收缩和腺体分泌。我们调查了麻醉期间曲马多对胃液pH值的影响，以确定曲马多是否抑制胃腺分泌。方法：招募了ASA身体状况I或II成年患者（n = 30），这些患者参加了上肢或乳房切除术的重大选择性骨科手术。患者被随机分配接受曲马多（n = 10），法莫替丁（n = 10）或生理盐水（n = 10）治疗。然后使用丙泊酚，维库溴铵和芬太尼进行全身麻醉。诱导麻醉后，使用pH试纸测量胃pH，然后将100 mg曲马多，20 mg法莫替丁或盐水注入三角肌中。手术开始三小时后，再次抽吸胃液并测量其胃液pH。结果：麻醉前三组之间的pH没有差异。相比之下，曲马多组的胃液pH值在服用药物3小时后与法莫替丁组相同。盐水，法莫替丁和曲马多组的胃pH分别为2.6 +/- 2.5、6.3 +/- 2.0和6.4 +/- 0.8。结论：这些结果表明曲马多抑制胃酸的分泌。

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