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首页> 外文期刊>Canadian journal of anesthesia: Journal canadien d'anesthesie >The addition of epidural morphine to ropivacaine improves epidural analgesia after lower abdominal surgery: (L'addition de morphine peridurale a la ropivacaine ameliore l'analgesie peridurale apres une intervention chirurgicale abdominale basse).
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The addition of epidural morphine to ropivacaine improves epidural analgesia after lower abdominal surgery: (L'addition de morphine peridurale a la ropivacaine ameliore l'analgesie peridurale apres une intervention chirurgicale abdominale basse).

机译：罗哌卡因中添加硬膜外吗啡可改善下腹部手术后的硬膜外镇痛作用：（在硬膜外腔中罗非卡因吗啡和硬膜外介入治疗）。

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PURPOSE: To assess the analgesic and side effects of the continuous epidural infusion of 0.2% ropivacaine combined with morphine compared to both drugs alone. METHODS: In this study, both observers and patients were blinded to patient group assignment. Sixty patients scheduled to undergo lower abdominal surgery were enrolled. Patients were randomized to one of three postoperative treatment groups: 1) combination group (a combination of 0.2% ropivacaine and 0.003% morphine); 2) morphine group (0.003% morphine); or 3) ropivacaine group (0.2% ropivacaine). Postoperatively, all solutions were administered epidurally at a rate of 6 mL.hr(-1) for 24 hr. Patients were given iv flurbiprofen as a supplemental analgesic on demand. RESULTS: The combination group showed lower visual analogue scale scores than those of patients receiving either drug alone, both at rest and on coughing. The combination group showed a slight motor block at two hours after the continuous epidural infusion, while the ropivacaine and morphine groups did not show any motor block. The incidence of itching was significantly increased in the morphine and combination groups, compared to the ropivacaine group. There was no significant difference between the numbers of patients with nausea in the three groups. No hypotension or respiratory complications were observed in the three groups. CONCLUSION: The combination of epidural 0.2% ropivacaine and 0.003% morphine has more effective analgesic effects than either of the drugs alone for postoperative pain relief after lower abdominal surgery.
机译：目的：评估与单独两种药物相比，连续硬膜外输注0.2％罗哌卡因联合吗啡的镇痛和副作用。方法：在这项研究中，观察者和患者都不知道患者分组。入选了计划进行下腹部手术的60名患者。患者被随机分为三个术后治疗组之一：1）联合治疗组（0.2％罗哌卡因和0.003％吗啡联合治疗）; 2）吗啡组（0.003％吗啡）;或3）罗哌卡因组（0.2％罗哌卡因）。术后，所有溶液均以6 mL.hr（-1）的速度硬膜外给药24小时。按需给患者静脉补充氟比洛芬作为补充镇痛药。结果：在静息和咳嗽时，联合治疗组的视觉模拟量表评分均低于单独接受两种药物治疗的患者。硬膜外连续输注两个小时后，联合组显示出轻微的运动障碍，而罗哌卡因和吗啡组未显示任何运动障碍。与罗哌卡因组相比，吗啡和联合用药组的瘙痒发生率显着增加。在三组中，恶心患者的数量之间没有显着差异。三组均未观察到低血压或呼吸系统并发症。结论：硬膜外0.2％罗哌卡因和0.003％吗啡的联合使用比单独使用任何一种药物对下腹部手术后的术后镇痛效果更佳。

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